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bodies which he had mistaken for ova. Carter (16) in 1875, found in an ulcer 
of the lymphatic spaces of the corium, the mycelium of a fungus which contained 
many spores and orange-colored granules. However, as other observers have 
remarked, Carter’s specimen had been kept for a long time in a weak preserving 
fluid which contained no alcohol and in which it probably became contaminated 
with the mold in question. In 1884, Deperet and Boinet, (17) in the study of 
an epidemic of Oriental boil among soldiers who returned from Tunis, culivated 
a cocecus from the lesions. This organism proved to be pathogenic for animals 
and upon injection produced nodules and ulcerations and sometimes a general 
infection. In the same year Duclaux and Heydenreich (18) also cultivated a 
miecrococeus which they believed to be specific, from cases of Biskra bouton. 
This organism, when injected into animals in small amounts, sometimes pro- 
duced a chronic lesion of the skin, which was said to bear some resemblance to 
that of Biskra bouton. In other cases the injection of this coccus caused the 
death of the animal within sixteen hours. Sufficiently accurate details for the 
identification of the organism are not given. 
In 1885 Cunningham (8) reported the discovery of peculiar parasitic organisms 
in a specimen of Delhi boil. The lesion, which was examined histologically, had 
been placed in alcohol immediately after its removal. The epidermis over the 
boil was still intact, there being no ulceration present. The organisms varied 
considerably in size and in form; in some cases they were circular, in others 
elliptical, and in others irregularly lobate. In the majority of the instances 
their contour was smooth, but in some it was of a more or less tuberculate 
character. In some specimens a very delicate cell wall was clearly visible; in 
others it was wholly unrecognizable, or only to be detected on careful and special 
serutiny. Cunningham further states: “The distinctness with which they appear 
in sections treated with Gentian violet is due to the elective staining by the 
dye, of the nucleoid bodies which they contain. The number of such bodies present 
in different cells is extremely variable. The cytoplasm in the gentian-violet speci- 
mens remains almost uncolored; in those in which fuchsin has likewise been 
employed it frequently shows a more or less pronounced red hue, The tubereu- 
late appearance presented by some of the cells is due to the numbers and size 
of the nucleoid bodies present in them, which in association form a mulberry- 
like mass pressing upon the cell wall and molding it to the inequalities of its 
surface. In certain cases appearances apparently corresponding with the occur- 
rence of processes of cell division are present, the bodies of the cells being strongly 
constricted so as to form two lobes connected by a narrow neck, or two distinet 
cells oceur which, from their relations to one another and the character of their 
opposed surfaces, seem to have just arisen and to be due to the completion of such 
a process, ‘The individual cells in some cases are closely packed among the sur- 
rounding lymphoid elements; however, in a large number of instances, they 
appear to lie in a limited clear space. The number of cells visible in individual 
sections and in different parts of the same section varies considerably. Entire 
fields may in certain places fail to show any at all. This failure may in many 
instances be due to imperfect success in staining, but, allowing for this, there can 
be no doubt that the numbers present in different parts of the tumor vary greatly. 
It is only quite exceptionally that any are present in the epidermal stratum. The 
continuous stratum of granulation tissue beneath the papillary layer is the site in 
which they occur in greatest quantity, but specimens are also frequently present 
in considerable numbers within the papillary eminences. Their distribution is 
not limited to the epidermal and dermal strata, for on passing downward to the 
subcutaneous tissues seattered specimens may be found in the very deepest 
parts.” Cunningham is inclined to regard these bodies as representing various 
