STUDIES UPON EXPERIMENTAL VARIOLA AND VACCINIA 
IN QUADRUMANA. 
By Water R. BRINCKERHOFF and E. KE. Tyzzer, with an introduction by 
W. T. COUNCILMAN. 
(from the Sears Laboratory of Pathology, Harvard University Medical School, 
Boston, and the Biological Laboratory, Bureau of Science.") 
CONTENTS. 
Introduction, p. 241. 
Critical Review of the Literature on Experimental Variola and Vac- 
cinia in Monkeys, p. 248. 
Studies upon Experimental Variola and Vaceinia in Quadrumana. 
PART I. 
Studies upon Experimental Vaccinia in the Philippine Monkey 
(Macacus cynomologus), p. 255. 
1. Vaccinia following inoculations of the Skin of the Monkey, p. 255. 
2. Vaccinial Keratitis in the Monkey, p. 265. 
3. Vaccinia following inoculation of the Mucous Membrane of the Monkey, 
p. 269. 
PART II. 
Studies upon Experimental Variola in Monkeys (Macacus cynomo- 
logus and M. nemestrinus), and in the Orang Utan (Simia satyrus), p. 
278. 
. Variola Inoculata following inoculation of the Skin in Monkeys, p. 278. 
. Variola Inoculata in the Orang Utan, p. 297. 
. Variolous Keratitis in the Monkey, p. 301. 
. Variola Inoculata following inoculation of the Mucous Membrane in the 
Monkey, p. 304. ; 
5. On the Occurrence of Variola vera in Monkeys and in the Orang Utan, 
p. 310. 
Be wD eH 
PART IIT. 
Studies upon the Immunity Reactions of the Monkey after Inoculation 
with Vaccine or with Variola Virus, p. 320. 
‘Walter R. Brinckerhoff, 8. B., M. D., Instructor in Pathology, Harvard Uni- 
versity, and Research Fellow of the Rockefeller Institute for Medical Research ; 
E. E. Tyzzer, A. M., M. D., Assistant in Pathology, Harvard University, and Pa- 
thologist to the Caroline Brewer Croft Cancer Research, and W. T. Councilman, 
M. D., Shattuck Professor of Pathological Anatomy of Harvard University. 
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