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Kight days. The lesions show a slight increase in the extent of the central 
crust. The vesicular zone has become entirely opaque in places. The axillary 
lymp nodes are much enlarged. On the right side they form a mass 2 centimeters 
im diameter. Body temperature 40° C. 
Nine days. The lesions present as flat-topped elevations consisting of a periph- 
eral vesicular ring which has becomé completely opaque, surrounding a macer- 
ated area where the crust has been picked off. The whole lesion is surrounded 
by a pink flush. Axillary lymph nodes enlarged but not so hard as before. Body 
temperature 39°.4 C. 
Ten days. The lesions show an elevated pink, somewhat ragged epithelial edge 
which surrounds an area which is in part crusted and in part ulcer-like. Axillary 
lymph nodes somewhat enlarged. Body temperature 39° C. 
From this time on the lesions simply showed the phenomena of repair and 
healed after a few days. 
Twenty-three days after the first vaccination the animal was again inoculated 
on the skin of the abdomen with vaccine virus No. 148. No reaction followed this 
inoculation. 
No. 96. Adult male Macacus cynomologus. Inoculated in 12 places on the skin 
of the abdomen with vaccine virus No. 236. Body temperature 39°.6 C. 
Twenty-four hours after inoculation the seratches show considerable elevation 
with some reddening of the surrounding skin but with no opacity. Body tem- 
perature 39°.2 C. 
Forty-eight hours. There is slight elevation and some opacity along the line of 
inoculation. Axillary lymph nodes slightly enlarged. Body temperature 38°.5 C. 
Three days. There is an irregular elevation with opacity beside the narrow 
crust which marks the line of inoculation. Axillary lymph nodes are distinctly 
enlarged. Body temperature 39° C. 
Four days. The elevation which borders the crust has increased somewhat, 
extending from 2 to 3 millimeters on each side, Axillary lymph nodes much 
enlarged. Body temperature 39° C. 
Five days, Around the crust is a narrow vesicular ring which is bordered 
peripherally by elevated and reddened epithelium. The lesion is now from 6 to 
8 millimeters wide. Axillary lymph nodes large and hard. Body temperature 
39°.8 C. 
Six days. The lesion presents as a sharply circumscribed elevation consisting 
of a depressed central yellow crust bordered by an elevated ring from 2 to 3 milli- 
meters broad which is opaque and vesicular near the crust and which is pink 
externally. Axillary lymph nodes enlarged, some measuring 1 centimeter in dia- 
meter. Body temperature 39°.2 C. 
Seven days. The lesion is the same as yesterday save that the crust has ex- 
tended and encroached upon the vesicular ring. Axillary lymph nodes enlarged 
and hard. Body temperature 38°.8 C. 
Eight days. The animal has picked off the crusts and the lesion presents a 
central excoriated area surrounded by the more or less ruptured vesicular ring. 
There is a distinct reddening of the skin about the lesion. Axillary lymph nodes 
enlarged and hard. Body temperature 39° C. 
Nine days. The crust has formed again in the center of the lesion and about 
this is to be made out the remnants of the vesicular ring. The areola persists. 
Axillary lymph nodes enlarged and hard. Body temperature 39° C. 
Ten days. From this time on the lesions have lost their specific chatacter and 
simply present the phenomena of healing. The axillary lymph nodes show a 
diminishing tumor and consistency but are harder than normal for a considerable 
time after the healing of the skin lesion. 
St hee, 
