258 
Twenty-three days after the original vaccination the animal was again inoc- 
ulated on the skin of the abdomen with vaccine virus No. 148. No reaction 
followed this second inoculation. 
No. 98. Adult male Macacus cynomologus. Inoculated in 12 places on the skin 
of the abdomen with vaccine virus No. 1, Lot No. 365. Body temperature 39°.4 C. 
Twenty-four hours after inoculation the scratches show slight elevation and 
opacity. Axillary lymph nodes normal. Body temperature 39° C, 
Forty-eight hours. About the inoculation the skin is slightly elevated and 
opaque. Axillary lymph nodes normal. Body temperature 39° C. 
Three days. There is some reddening and marked elevation and opacity of the 
skin which borders the narrow crust which marks the line of inoculation. Axillary 
lymph nodes distinctly enlarged. Body temperature 39° C. 
Four days. The central crust has increased in extent and is surrounded by a 
pink elevation from 2 to 3 millimeters broad. Axillary lymph nodes enlarged. 
Body temperature 38°.4 C. 
Five days. The skin immediately about the central crust is slightly translu- 
cent, suggesting beginning vesicle formation. Axillary lymph nodes enlarged and 
hard. Body temperature 39°.5 C. 
Six days. The lesion presents a depressed yellow-brown crust which is sur- 
rounded by an elevated ring which is sharply circumscribed and is translucent 
near the crust. Axillary lymph nodes enlarged and hard. Body temperature 
39° C. 
Seven days. The vesicular ring about the central crust is now more or less 
opaque. There is distinct areola. Axillary lymph nodes enlarged and hard. 
Body temperature 39°.8 C. 
Fight days. Lesions present same features as yesterday save that there is 
some induration of the subcutaneous tissue beneath the lesions. Axillary lymph 
nodes very much enlarged. Body temperature 40°.2 C. 
Nine days. The central crust has begun to encroach upon the vesicular ring and 
the areola is less marked. Some degree of subcutaneous edema persists. Axillary 
lymph nodes enlarged and hard. Body temperature 40° C. 
Ten days. The lesions are still active but only remnants of the vesicle can be 
made out about the spreading crust. From this time on the lesions lose their 
specific characters. The enlargement and induration of the axillary lymph nodes 
suffer a continuous diminution, although the consistency is greater than normally 
for some days after the healing of the specific lesion is complete. 
Twenty-three days after the first inoculation the animal was inoculated again 
on the skin of the abdomen with vaccine virus No. 148, but no reaction followed. 
No. 101. Adult male Macacus cynomologus. Inoculated in 12 places on the 
skin of the abdomen with vaccine virus No. 246. Body temperature 39°.2 C. 
Twenty-four hours after inoculation the scratches show a slight opacity but no 
elevation. Axillary lymph nodes normal. Body temperature 39°.8 C, 
Forty-eight hours. There is now some elevation as well as opacity along the 
line of inoculation. Axillary lymph nodes normal. Body temperature 37°.8 C. 
Three days. The elevation and opacity is more marked and now extends for a 
distance of 2 or more millimeters on each side of the scratch. Axillary lymph 
nodes slightly enlarged. Body temperature 39° C. 
Four days. The lesions present as irregular pink elevations which are sur- 
mounted by a narrow linear crust which occupies the site of the inoculation 
seratch. Axillary lymph nodes slightly enlarged. Body temperature 39° C. 
Five days. Lesions show a depressed central crust bordered by an elevated 
zone which is translucent near the crust. The whole lesion measures 8 milli- 
meters across. Axillary lymph nodes enlarged. Body temperature 39° C. 
