259 
Six days. The central crust has enlarged and the surrounding elevated ring is 
opaque and vesicular for 2 millimeters about the crust. The areola is bright and 
the whole lesion sharply circumscribed. Axillary lymph nodes enlarged. Body 
temperature 39° C, 
Seven days. The lesion is the same as yesterday save for an increase in the 
area of the crust and a filling out of the vesicular ring. Axillary lymph nodes 
slightly enlarged. Body temperature 40° C. 
Kight days. Lesion shows the same features but the whole lesion has ceased to 
spread. The depression of the central crust is marked. Axillary lymph nodes 
enlarged and hard. Body temperature 38°.8 C. 
Nine days. The crust has been picked off and the lesion presents an excoriated 
area about which the remnants of the vesicle can be made out. Axillary lymph 
nodes less enlarged but hard. Body temperature 39°.4 C, 
Ten days. The lesions are now healing and have lost their specifie characters. 
Axillary lymph nodes but slightly enlarged. Body temperature 39°.6 C. 
The further course of the lesions showed only the healing process. The axillary 
lymph nodes were of normal size and of only slightly increased consistency. In 
this case the lymph nodes did not show as much reaction as is usual after skin 
inoculation with vaccine. 
Twenty-three days after the original inoculation the monkey was vaccinated a 
second time on the skin of the abdomen with vaccine virus No. 148. No reaction 
followed the second inoculation. 
No. 105. Adult male Macacus cynomologus. Inoculated in 12 places on the 
skin of the abdomen with vaccine virus No. 148. Body temperature 40° C. 
Twenty-four hours after inoculation the scratches show no reaction. A narrow 
crust marks the line of each inoculation, Axillary lymph nodes normal.‘ Body 
temperature 39°.5 C, 
Forty-eight hours. There is a slight elevation which is opaque and a faint pink 
color about the crust. Axillary lymph nodes normal. Body temperature 38°.8 C. 
Three days. About the scratch the epithelium is elevated, opaque, and pink for 
a distance of 2 or more millimeters. On pressure a small amount of clear serum 
oozes from under the crust. Axillary lymph nodes slightly enlarged. Body tem- 
perature 38° C. 
Four days. The lesion presents as a sharply circumscribed, pink elevation 
3 millimeters in width which surrounds a slightly depressed crust. Axillary 
lymph nodes enlarged. Body temperature 39°.8 C. 
Five days. The central crust has enlarged and there is a translucent vesicular 
ring. Axillary lymph nodes enlarged and hard. Body temperature 39°.8 C. 
Six days. The depressed yellow central crust is now bordered’ by an elevated 
ring in which can be distinguished an opaque, yellowish zone which merges with 
a translucent band of a gray color. The areola is distinct and bright red. Axil- 
lary lymph nodes enlarged. Body temperature 39°.6 C. , 
Seven days. The lesion has attained a total width of 1 centimeter. Some 
subcutaneous edema is apparent. Axillary lymph nodes enlarged and hard. 
Body temperature 39°.8 C. 
Eight days. Lesions show same features as yesterday. Axillary lymph nodes 
slightly enlarged. Body temperature 40°.1 C. 
Nine days. The crusts have been picked from the lesions and have left an 
excoriated area surrounded by a ragged, opaque, epithelial edge about which the 
skin is reddened. Axillary lymph nodes enlarged. Body temperature 39° C. 
Ten days. From this time on the lesions show simple repair. The axillary 
lymph nodes were more or less enlarged and hard for some time. 
397144 
V 
72°53" 
~-_e 
