270 
Twenty-four hours after the inoculation no process was visible at the site of 
the incisions. Body temperature 38°.5 C. 
Forty-eight hours. In the nose the inoculation scratch is just visible. The 
lip presents a small white spot. The palate shows a minute, white papule 1 
millimeter or less in diameter. Body temperature 38° C. 
Three days. Nose: Some elevation and opacity of the mucous membrane about 
a small brown area. Lip: Three circular opaque white areas, 2 millimeters in 
diameter, along the line of inoculation. Each of these opaque areas shows a 
minute central pink spot. Palate: In the inoculated area are two small, slightly 
elevated, opaque white spots, about 2 millimeters in diameter, each with a 
minute central pink dot and surrounded by an areola, Body temperature 
38°.4 C. 
Four days. Nose: An opaque white elevation, just inside the orifice. Lip: An 
elevated opaque white area, 3 X 6 millimeters, the center of which is macerated 
and which is surrounded by a distinct red flush. Palate: An oval area, 3 X 4 
millimeters, opaque-white, with 2 minute translucent dots near the center, The 2 
areas noted yesterday have fused. Marked peripheral pink flush. Body tem- 
perature 30° C. 
Five days. Nose: Left orifice almost closed by swelling of mucous membrane. 
On the anterior portion of the left side of the septum is an elevated, white area 
surmounted by a small vesicle surrounding a small yellow crust. Lip: The lesion 
presents an eroded area with an elevated ragged edge, 10 X 5 millimeters in 
extent and surrounded by a distinct areola. No trace of vesicle formation can 
be made out, the lesion being essentially an ulcer. Palate: An elevated opaque 
white area, 5 X 3 millimeters, with gray, semitranslucent center and surrounded 
by an aerola. Body temperature 39°.2 C. Animal chloroformed and autopsy 
done at once. Primary lesions as described. No evidence of a septic lesion found 
in gastro-intestinal tract. Viscera normal. 
No. 82. Adult male M. cynomologus. Inoculated on mucous membrane of 
nose, lip, and palate with vaccine virus No. 1. Body temperature 39°.5 C. 
Twenty-four hours after the inoculation the mucous membrane shows no 
macroscopic lesion. Body temperature 39°.5 C. 
Forty-eight hours. A small, white area is visible in the nose and a similar 
spot is seen at the site of inoculation on the lip. The palate shows no lesion. 
Body temperature 38°.8 C. 
Three days. Nose: A pink elevation is visible. Lip: A white, opaque area, 
2X 5 millimeters, is apparent along the line of inoculation. The mucous mem- 
brane over this area-is more or less macerated, and about the area there is a 
distinct red flush. Palate: A single translucent papular elevation, 2 millimeters 
in diameter, with a minute opaque central dot is seen on the line of inoculation. 
Body temperature 39°.2 C. 
Four days. Nose: A number of minute elevated opaque areas surrounded by a 
pink flush. Lip: An excoriated, bleeding area, 6 < 3 millimeters, with an elevated, 
opaque, white edge and surrounded by a distinct areola. Palate: An opaque, white 
area with an elevated margin and surrounded by a red areola, Body temperature 
39°.5 C. , 
Five days. Nose: A grayish elevation with a pink margin. Lip: An elevated 
opaque white area, 10 x 6 millimeters, with some erosion of the surface and with 
a sharp border which is surrounded by a red areola. Palate: An elevated, gray- 
yellow area, 8 X 3 millimeters, presenting several minute, bleeding points and a 
bright red areola. 
Six days. Nose: Inspection difficult and findings indefinite. Lip: Lesion as 
before but somewhat increased in extent. Palate: Lesion as yesterday save that 
it has spread a little. Body temperature 40° C. 
