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white area, 2 X 2 millimeters, with a distinct pink flush about it. Palate: 
2 white elevations, 2 millimeters in diameter, flat-topped, and 1 millimeter in 
height, surrounded by an areola. Body temperature 39°.8 C. 
Five days. Nose: Some degree of ‘erosion of the mucous membrane of the sep- 
tum at the site of inoculation. Lip: An area, 8 X 4 millimeters, presents an 
elevated, somewhat ragged, white edge, an eroded central portion, and a cireum- 
ferential, pink flush. Palate: Elevated area, 8 X 3 millimeters, with a grayish- 
white center and a pink periphery. The nostril presents a vesicle which has 
spread from the mucous surface out upon the skin. Body temperature 39°.6 C. 
Six days. Nose: Left nostril almost occluded by swelling of the mucous mem- 
brane and by yellow crusts. Lip: Lesion presents same features as yesterday. 
Palate: Lesion has enlarged somewhat and the central portion has a yellow color. 
Body temperature 39°.8 C. 
Seven days. Body temperature 39°.5 C. Animal chloroformed. Nose: Along 
edge of nostril is a shallow excoriation, from which oozes a partly clear and partly 
cloudy fluid. The septum presents irregular, opaque, white elevations along the 
line of the inoculation. Lip: Lesion as before, save that loss of substance is 
more marked and there is some bleeding. Palate: Lesion as before, Viscera 
appear normal. 
No. 86. Full grown female M. cynomologus. Inoculated in nose, on lip, and on 
soft palate with vaccine virus No. 1. Body temperature 39° C. 
Twenty-four hours after the inoculation no evidence of a specifie process is 
visible on inspection. Body temperature 39°.2 C. 
Forty-eight hours. Nose: A narrow crust marks the site of the inoculation. 
Lip and palate negative. Body temperature 39° C. 
Three days. Lesions show no change since yesterday. Body temperature 38° C. 
Four days. Nose: White elevation at site of inoculation. Lip and palate 
negative. Body temperature 39° C. 
Five days. Nose: An elevation 2 millimeters wide on septum near edge, with 
central loss of substances Lip and palate negative. Body temperature 38°.2 C. 
Six days. Nose: Left nostril almost closed by swelling of mucous membrane and 
yellow crusts. Inspection of interior not possible. Lip and palate negative. 
Body temperature 39° C. 
Seven days. Nose: Edge of nostril presents a shallow erosion partly covered 
by a yellow crust. Lip and palate negative. Body temperature 39° C. 
Eight days. Nose: Excoriation about nostril persists. Swelling of mucous 
membrane less marked. Lip and palate show no lesion. Body temperature 39° C, 
Nine days. Nose: Lesion at edge of nostril from this time on heals like any 
vaccination of the skin. Animal allowed to survive. Twenty-two days after the 
first inoculation the monkey was inoculated again with vaccine virus No. 1. 
No lesion followed. 
No. 87. Full grown male M. cynomologus, Animal inoculated in nose, on lip, 
and on soft palate with vaccine virus No. 1. Body temperature 39° C, 
Twenty-four hours after inoculation the nose is negative, while the lip and 
palate show a red line on the mucosa at the site of the incision. Body tem- 
perature 39°.4 C, 
Forty-eight hours. Nose: The inoculation scratch is now visible. Lip negative. 
Palate: Small red area at site of inoculation. Body temperature 38° C. 
Three days. Nose: Mucosa pink, lesion not definite. Lip: A white line 3 
millimeters long and 1 millimeter broad marks the site of the inoculation. 
Palate: Shows a white papular elevation 1 millimeter in diameter surrounded by 
a pink flush. Body temperature 39° C. 
