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Four days. Nose: White elevation with a pink flush about it. Lip negative. 
Palate: Opaque, white, oval, elevated area, 2 x 3 millimeters, with a translucent 
center and a pink peripheral flush. Body temperature 39°.2 C. 
Five days. Nose: Left side of the septum and the roof of the left nostril 
swollen; considerable mucous discharge. A translucent vesicle is present at the 
edge of the nostril. Lip: No lesion. Palate: A gray-white elevation, 2 X 3 mil- 
limeters, surrounded by a pink flush. Body temperature 40° C. 
Six days. Nose: Left nostril all but occluded by a mass of yellow crusts 
springing from the septum: and the upper border of the nostril. Lip negative. 
Palate: Oval area with an elevated, opaque, white edge, an eroded, pink center, 
and a distinct red areola. Body temperature 40° C, 
Seven days. Nose: Lesions at edge of nostril extending and involving skin. 
Inspection of mucous membrane not possible on account of crusts and swelling. 
Lip negative: Palate: Lesion measures 6 X 4 millimeters, edge sharply cireum- 
scribed, elevated and gray-white, central portion gray and eroded. Body tem- 
perature 39°.5 C. 
Fight days. Nose: Left nostril presents an opaque, white elevation, which bulges 
out from the septum and from the upper border of the orifice. The lesion at 
the edge of the nostril has extended somewhat on the skin surface. Lip negative. 
Palate: Lesion presents same features as yesterday. Body temperature 39° C. 
Nine days. Nose: Lesion less extensive than before. Lip negative. Palate: 
Lesion presents same features as yesterday. Body temperature 39° C. Animal 
chloroformed. At autopsy no specific lesions found other than those at sites of 
inoculation. 
No. 88. Adult male M. eynomologus. Inoculated inside of nose, on lip, and on 
soft palate with vaccine virus No. 1. Body temperature 39° C. 
Twenty-four hours after inoculation no reaction is visible. Body temperature 
38°.6 C. 
Forty-eight hours. Nose: A narrow, dark-red crust marks the line of in- 
oculation. Lip: Mucous membrane reddened about scratch. Palate: An area 2 
millimeters in diameter with an opaque white center and a deep red flush about 
it seen at the point of inoculation. Body temperature 38° C. 
Three days. Nose: Narrow, brownish, depressed line bordered by an elevation 
the color of the mucous membrane. Lip: A line 1 millimeter wide, opaque-white 
in color, occupies the site of the scratch. About this line the mucous membrane 
is reddened. Palate: A narrow, irregular, white line bordered by an areola, the 
whole somewhat elevated, is visible at the site of inoculation. Body temperature 
38°.2 C. 
Four days. Nose: Mucous membrane injected but no definite lesion can be made 
out. Lip: An opaque, white area, 6 X 2 millimeters with small area of loss of 
substance and surrounded by a red areola. Palate: An oval area, 2 X 4 milli- 
meters, slightly elevated, and seated on reddened mucous membrane. Body tem- 
perature 38°.5 C. 
Five days. Nose: Some muco-purulent discharge from the left nostril. A 
white elevation with a pink border is visible on the septum. Lip: Opaque, white 
elevated area, 8 X 2 millimeters, with some superficial loss of substance and with a 
red areola. Palate: 2 lesions present, one 6 X 2 millimeters and one 2X 2 
millimeters. Both lesions are slightly elevated and present a gray center, a white 
periphery, and a red areola. Body temperature 38°.8 C. 
Six days. Lesions same as yesterday save that they have extended somewhat. 
Body temperature 39°°C. Animal chloroformed and an autopsy done at once. 
Specific lesions as described. No evidence of vaccinal lesions found in respiratory 
or digestive tract. 
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