280 
7 millimeters across. In some there is a narrow translucent zone immediately 
around the crust. Axillary lymph nodes somewhat enlarged and firm. Body 
temperature 40° C. 
Five days. The central crust is depressed, and is surrounded by a definitely 
elevated vesicular ring, which is bordered externally by a red areola, fading 
outwards into normal skin. There is much @dema of the subcutaneous tissue 
beneath the lesions, producing a broad indurated base on which the lesions are 
individually prominent. The lesions average 8 millimeters in width. Axillary 
lymph nodes distinctly enlarged and hard. Body temperature 41°.5 C. 
Six days. Both the crust and the vesicle have increased in extent. The contour 
of the lesion shows an abrupt elevation in the zone of the areola. Average width, 
10 millimeters. A few small red papules are noted on the shaved area of the 
abdomen near the belt line. Axillary lymph nodes enlarged and hard. Body 
temperature 40°.8 C. 
Seven days. The lesion presents as a flat-topped elevation with a central 
brown crust and an opaque vesicular ring. Average width 8 millimeters. The 
lesions are less prominent to-day, owing to the subsidence of the subcutaneous 
«edema. Two of the papules noted near the belt line have increased somewhat 
in size. Axillary lymph nodes as before. Body temperature 40° C. 
Eight days. Primary lesions are beginning to undergo involution, the crust is 
spreading at the expense of the vesicular ring. Subcutaneous edema has almost 
disappeared. On the face there are a dozen or more papules and vesicles from 
2 to 4 millimeters in diameter. Similar lesions are present on the abdomen, 
the scrotum, the inner aspect of the thighs, and on the palms. Axillary lymph 
nodes as before. Body temperature 40° C. 
Nine days. The vesicular element in the primary lesions has been obliterated 
by the spreading of the central crust. The lesions of the exanthem are present as 
filled out vesicles, some of which have opaque, white or yellow contents, and all 
are surrounded by a bright-red areola, An abundant eruption is noted on the tail 
and the skin about its base. Axillary lymph nodes slightly enlarged and hard. 
Body temperature 39°.5 C. 
Ten days. Many of the primary lesions have been scratched and are present as 
shallow ulcerations over which the epithelium is spreading from the edge. The 
lesions no longer present specific characters. The lesions of the exanthem are dry 
and crusted. The eruption is noted to-day on the soles and on the dorsal aspect 
of several of the fingers and toes. Axillary lymph nodes of almost normal size 
but still firmer than normally. Body temperature 38°.5 C. 
From this time on the specific lesions healed without complications. Material 
was collected at intervals for the histological study of the primary lesions. 
No. 115. Half-grown male, Macacus cynomologus. Inoculated in 12 places on 
the abdomen with virus No. 167 (vesicle contents). Body temperature 38° C. 
Eighteen hours after the inoculation a narrow, brown crust, surrounded by a 
sharply circumscribed, elevated, opaque, white area 5 millimeters across, marks 
the site of the inoculation. Body temperature 39°.4 C. 
Forty-eight hours. The skin about the crust is elevated and pink for a dis- 
tance of 2 millimeters. Body temperature 37°.8 C. 
Three days. The elevated area has increased in extent and is distinctly red in 
color. Axillary lymph nodes slightly enlarged. Body temperature 38°.8 C. 
Four days. Immediately about the crust there is a distinct translucence of 
the skin. Average width of lesions, 7 millimeters. Axillary lymph nodes dis- 
tinctly enlarged. Body temperature 39°.5 C. 
Five days. The lesion is present as a rounded elevation surmounted by a 
narrow, brown crust, about which there is a distinct vesicular ring, translucent 
