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near the crust and shading insensibly into a pink zone, which fades out into the 
surrounding normal skin. Considerable subcutaneous edema. Average width 
of lesions, 8 millimeters. Axillary lymph nodes distinctly enlarged and hard. 
Body temperature 41°.5 C. 
Six days. The central crust is surrounded by a narrow, opaque, white vesicle 
on a pink elevation, measuring from 9 to 10 millimeters across. Axillary lymph 
nodes as before. Body temperature 39°.8 C. 
Seven days. The lesions present as flat-topped, sharply circumscribed eleva- 
tions, from 9 to 10 millimeters in diameter. The central crust, somewhat 
depressed, is surrounded by an elevated vesicular ring which is opaque-white in 
color. On the upper lip, the abdomen, the arm, and the scrotum are seen small, 
red, papular elevations. Axillary lymph nodes as before. Body temperature 
39°.8 C. 
Eight days. Yellow, turbid fluid oozes from beneath the central crust. The 
vesicular ring has been obliterated in places by the spreading of the crust. The 
lesions of the exanthem are somewhat larger and vesicular. Three new lesions 
have appeared on the face and one in the groin. Lymph nodes as before. Body 
temperature 39°.5 C. 
Nine days. The vesicular zone of the primary lesion has been entirely obliterated. 
The subcutaneous edema has almost disappeared. To-day an exanthem is noted 
at the edge of the nostril and in the vestibule. The tail and the skin at its base 
present numerous small papules and vesicles, each surrounded by a distinct areola. 
Axillary lymph nodes enlarged and hard. Body temperature 39°.5 C. 
Ten days. Primary lesions are healing and present no specific characters. The 
lesions of the exanthem have dried and are healing. One eruptive lesion found 
on the sole of the foot and several on the dorsal aspect of the toes. Axillary 
lymph nodes of almost normal size but still firm. Body temperature 39°.5 C. 
No. 116. Young, adult male, Macacus cynomologus. Inoculated in 12 places 
on the skin of the abdomen with virus No. 167 (vesicle contents). Body temper- 
ature 38°.5 OC. 
Eighteen hours after the inoculation the skin about the scratch is slightly 
elevated and opaque for distance of 2 millimeters. Body temperature 38°.6 C. 
Forty-eight hours. The site of inoculation is marked by a narrow, yellow 
crust surrounded by a pink elevation 3 millimeters in width. Body temperature 
37°.8 C. 
Three days. The primary lesion as before, save that the elevation is more 
marked and the color deeper. Axillary lymph nodes slightly enlarged. Body 
temperature 40° C. 
Four days. The brown, central crust is seated upon a pink elevation 6 to 10 
millimeters across, which fades out into the normal skin. Immediately about 
the crust there is a narrow zone of translucence suggesting vesicle formation. A 
marked subcutaneous cedema renders the lesions prominent. Axillary lymph 
nodes enlarged and hard. Body temperature 40° C. 
Five days. Primary lesion as before but it has increased in size. Axillary 
lymph nodes markedly enlarged and hard. Body temperature 41° C. 
Six days. The crust is surrounded by a definite vesicular ring, which in turn 
is surrounded by a dull pink areola. Average width of lesions, 9 millimeters. 
Axillary lymph nodes as before. Body temperature 39°.5 C. 
Seven days. The primary lesions present as circumscribed elevations with a 
central, depressed, brown crust, an elevated, opaque-white, vesicular ring, and a 
bright-red areola. Average width of lesions 9 millimeters. On the face, the 
abdomen, the scrotum, the thighs, and the arms are numerous small papules or 
vesicles, each surrounded by a red areola. Axillary lymph nodes as before. Body 
temperature 39°.8 C. 
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