282 
Eight days. Primary lesions no longer show a vesicle. Many of the papules 
have become vesicles and the vesicles pustules. There is some increase in size 
of the lesions of the exanthem. Axillary lymph nodes as before. Body tempera- 
ture 40° C. 
Nine days. Some subcutaneous edema persists beneath the primary lesions, 
which, however, have lost their specific character. The exanthem is beginning 
to dry on the face. Many papules and vesicles, not noted before, are visible on 
the tail and on the skin at its base. Axillary lymph nodes enlarged and hard. 
Body temperature 39°.5 C. 
Ten days. The primary lesions are healing. Eruptive lesions found to-day on 
soles and palms. Axillary lymph nodes still enlarged and hard. Body temper- 
ature 39°.6 C. 
No. 117. Adult male, Macacus cynomologus. Inoculated with same virus and 
in the same way as the preceding animals. Body temperature 37°.8 C. 
Eighteen hours after inoculation a narrow yellow crust is seen upon an opaque, 
slightly elevated area, Body temperature 39°.2 C. 
Forty-eight hours. The elevation and opacity have extended somewhat. Body 
temperature 37°.2 C. 
Three days. The lesion presents a linear crust on a slightly elevated, pink 
area 4 millimeters across. Axillary lymph nodes slightly enlarged. Body tem- 
perature 39° C. 
Four days. About the crust is a narrow translucent zone which merges with 
the pink elevation, which in turn fades off into the surrounding skin. Average 
width of lesions, 7 millimeters. Axillary lymph nodes distinctly enlarged and 
hard. Body temperature 39°.5 C. 
Five days. A distinct but narrow vesicle is evident around the crust. Con- 
siderable edema beneath the lesions. Areola well marked. Axillary lymph nodes 
as before. Body temperature 40°.5 C. 
Six days. Certain of the lesions show a typical development presenting a 
crust, a definite vesicle, and an areola, the whole lesion being sharply elevated 
from the surrounding skin. Other lesions show departure from the normal type 
in that the vesiculation is less marked and the lesions are not as sharply cir- 
cumseribed. Lymph nodes enlarged and hard. Body temperature 40°.2 C. 
Seven days. Some lesions typical, others show a spreading of the crust with- 
out macroscopic evidence of vesicle formation. Average width of lesions 9 mil- 
limeters. On the face, abdomen, scrotum, inner aspect of thighs, axille, and arms 
are numerous pink, papular elevations 2 millimeters in diameter, some of which 
present translucent central points. Axillary lymph nodes as before. Body tem- 
perature 39°.6 C. 
Fight days. Certain of the primary lesions show remnants of the vesicle at 
the edge of the spreading central crust. The lesions of the exanthem have 
increased in size and the contents of many of the vesicles has become cloudy. 
New eruptive lesions are present on the abdomen. Axillary lymph nodes as 
before. Body temperature 39°.8 C. 
Nine days. The primary lesions show a narrow zone of translucent epithelium 
close to the crust. This appearance suggests the beginning of the healing of the 
lesion by the ingrowth of new epithelium rather than vesicle formation. Lesions 
of the exanthem have dried up with or without rupturing. Axillary lymph nodes 
slightly enlarged but firmer than normal. Body temperature 39°.5 C. 
Ten days. The healing of the primary lesions is well under way, and they have 
lost all specifie character. To-day an exanthem is noted in the region about the 
ischial tuberosities and beneath the tail. Eleven eruptive lesions found in the 
palms and soles and many are also present on the fingers and toes. Axillary 
