— 
r i= 7 ’ “TY de ts a. 
-* vars PEL a ae ——? 
283 
lymph nodes slightly enlarged and hard. Body temperature 39° C. Specific 
lesions healed without complications. 
No. 118. Adult, male, Macacus cynomologus. Inoculated with the same virus 
and in the same manner as the previous animals. Body temperature 38°.8 C. 
Eighteen hours after inoculation. Some elevation and opacity is evident about 
the scratch. Body temperature 38°.5 C. 
Forty-eight hours. Elevation and opacity more marked. Body temperature 
37°.4 C. 
Three days. Lesion presents as a narrow, yellow crust on a pink elevation 5 
millimeters across. Axillary lymph nodes slightly enlarged. Body tempera- 
ture 39° C. 
Four days. <A narrow zone of translucence is visible near the central crust. 
The lesion is roundly elevated, of a pink color, and merges without sharp line of 
demarcation with the surrounding skin. Average width of lesion, 7 millimeters. 
Considerable subcutaneous edema. Axillary lymph nodes enlarged. Body tem- 
perature 39°.6 C, 
Five days. A definite vesicular ring surrounds the crust and is surrounded in 
turn by a pink areola. The lesion is not sharply circumscribed. Axillary lymph 
nodes enlarged and hard. Body temperature 41°.2 C. 
Six days. The vesicular ring has become opaque and has increased in extent. 
There is some diversity in the size of the lesions. Axillary lymph nodes as 
before. Body temperature 40°.6 C. 
Seven days. The central crust is surrounded by an elevated ring in which evi- 
dence of vesiculation can be made out in places. The edge of the lesion is 
sharply circumscribed and rises abruptly from the surrounding skin. A definite 
pink areola is present. Average width of lesions, 9 millimeters. On the face, 
inner aspect of arms, thighs, and abdomen are red, papular elevations 2 milli- 
meters in diameter. Some of these present a minute translucent center. Axillary 
lymph nodes as before. Body temperature 40°.2 C. 
Eight days. Involution of primary lesions has begun. The vesicular ring has 
entirely been obliterated by the spreading of the central crust. The subcutaneous 
edema has disappeared. The lesions of the exanthem have increased in size and 
are definitely vesicular. Some new papules are present today upon the abdomen 
and face. Axillary lymph nodes of normal size but firmer than normal. Body 
temperature 40°.2 C. 
Nine days. Primary lesions beginning to heal. The exanthem is dry and no 
new lesions have appeared. Axillary lymph nodes as before. Body temperature 
39°. C. 
Ten days. Primary lesions not notable. Eruptive lesions, not noted before, are 
present on the palms. Axillary lymph nodes as before. Body temperature 39° C. 
No. 170. Adult male, Macacus cynomologus. Inoculated in 6 places on the 
skin of the abdomen with a suspension of pulverized disks (virus No. 167) in 
sterile salt solution. 
Three days. An opaque elevation 3 millimeters across is present at the side 
of inoculation. Body temperature 39° C. 
Five days. Lesion presents a small crust on a pink elevation 5 millimeters 
across. A narrow zone of translucence borders the crust. Body temperature 
39° C. 
Six days. The central crust is depressed and about it there is irregular vesicle 
formation. The lesions vary much in size. Body temperature 40° C. 
Seven days. Primary lesions have increased slightly in extent. Considerable 
subcutaneous cedema is present. Body temperature 39°.5 C. 
