, oh 
284 
Eight days. Some of the primary lesions show a distinct but irregularly 
developed vesicular zone. Near anus is a single vesicle 2 millimeters across 
surrounded by a red areola. 
Nine days. The central crust has encroached upon and partly obliterated the 
vesicular zone. Single small vesicles are present on the arm, the thigh, beneath 
the tail, and on the ankle. 
Ten days. Primary lesions healing. No new exanthem. 
No. 171. Inoculated with the same virus and in the same manner as the pre- 
ceding monkey. 
The evolution of the primary lesion was delayed and the vesiculation irregular, 
as in the previous experiment. No general exanthem was observed. The temper- 
ature reaction was indefinite. 
No. 164. Half grown male, Macacus cynomologus. Inoculated in 6 places on 
the skin of the abdomen with a suspension of pustular contents [ (virus No. 167), 
dried with lyecopodium powder] in sterile salt solution. 
Twenty-four hours after inoculation there is slight elevation and opacity about 
the seratches. 
Subsequent to this, for a period of 5 days after the inoculation, there is no 
evidence of a process. ; 
Six days. Lesions present a narrow crust on a pink elevation. The appearance 
is the same as that seen on the third day after an inoculation with fresh vesicle 
contents. 
Seven days. The lesion has increased somewhat in extent and is sharply 
circumscribed. 
Hight days. An irregular vesicular zone is developed about the crust. 
Ten days. Vesiculation no longer apparent. But slight induration can be 
made out in the lesion. No general exanthem was observed either before or after 
this date. The animal was subsequently inoculated with vaccine virus No. 1, but 
failed to react. 
No. 194. Young male, Macacus nemistrinus. Inoculated in 12 places on the 
skin of the abdomen with virus No, 199. Body temperature 38°.8 C. 
Twenty-four hours after inoculation there is slight elevation and opacity about 
the seratch. Body temperature 37°.8 C. 
Forty-eight hours. Marked elevation and opacity around the linear crust. 
Body temperature 39°.1 C. 
Three days. There is marked subcutaneous edema beneath the lesion, The 
elevation about the crust is distinctly pink in color. Body temperature 38°.9 C. 
Four days. The lesion consists of a rounded, pink elevation 5 millimeters 
across, surmounted by a crust about which is a narrow zone of translucence, the 
whole lesion being underlaid by a broad indurated area of subcutaneous oedema. 
Body temperature 39°.3 C. 
Five days. An irregular development of the vesicular ring is apparent in certain 
of the lesions. Body temperature 39°.5 C. 
Six days. Many of the primary lesions have been scratched by the animal and 
are present as excoriated areas surrounded by a red elevation and seated upon a 
broad indurated base. Body temperature 39°.6 C. 
Seven days. Primary lesions as before. A profuse exanthem consisting of 
small, red papules and vesicles is present upon the face, trunk, and extremities. 
Body temperature 38°.7 C. : 
Fight days. The primary lesions have crusted and in places there is slight 
vesicle formation. Several new papules and vesicles are present on the face and 
thighs. One small vesicle is visible on the hard palate. Body temperature 38° C, 
