290 
The extent of the exanthem varied greatly. In some animals only 1 
typical lesion was present, while in others over 100 were found. 
The distribution of the exanthem showed a partiality for certain 
regions. The face was most often the site of an eruption. Elsewhere, 
roughly in the order of frequency, it was present upon the wrists, the 
scrotum of the male, the region about the anus and base of the tail, on 
the palms of the hands and the soles of the feet, and on the inner aspect 
of the arms and thighs. The eruption seemed to avoid the trunk and the 
outer hairy surfaces of the limbs. 
The evolution of the exanthem was rather constant. The first appear- 
ance of the eruption was as minute, pink papules, rarely exceeding 1 
millimeter in diameter. On the next day this papule was larger, often 
measuring 2 millimeters and showing a vesicular structure. In the 
majority of cases the fluid contents of the lesion became cloudy on the 
next day, and the lesion was completely dried in another 24 hours. The 
exanthem, therefore, has its complete evolution in about 4 days. In 
some animals the lesions pass through a longer period of development. 
In such lesions the papular, vesicular, and pustular stages could be 
recognized with as much certainty as in the primary lesions or as in the 
eruptive lesions of variola vera of man. ‘The phenomenon was noted of 
the lesions appearing first on the face and later on other parts of the 
body and of their drying up in the order of their appearance. 
The constitutional reaction, aside from the temperature, which might 
be taken as an indicator of the general reaction of the inoculated animal, 
showed little of a definite nature. At a time when the primary lesion. is 
in its active stage, about the sixth to the eighth day of the disease, the 
animal sometimes shows some degree of anorexia and a tendency to droop, 
but at no time does it present such a constitutional reaction as is seen in 
the case of variola vera, of even moderate severity, in man. 
The temperature reaction in variola inoculata in the monkey, differing 
from the same condition in its companion disease, vaccinia, presents a 
very definite curve. A comparison of the temperature charts of 20 
animals, inoculated on the skin of the abdomen with vesicle contents, 
shows a marked rise in the body temperature on the sixth day of the 
disease in 14, on the seventh day of the disease in 2, and an indefinite 
one in 4. In only 3 of the animals was there no distinct elevation. This 
onset temperature may reach 41° C. In most cases the fever declines 
by lysis. The temperature reaction precedes the appearance of the 
exanthem by 24 to 48 hours. 
The lymph nodes, which are interposed between the area of skin on 
which the primary lesion develops and the main lymph trunks, show a 
definite reaction. On the fourth or fifth day of the disease they are 
increased in size. This tumefaction increases and may, when the in- 
oculation is on the abdomen, result in an enlargement of the individual 
nodes in the axilla to a diameter of 1 centimeter or more. At the time 
