o—ee 
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day of the disease and has a duration of about 5 days, the first 2 of which 
are employed in growth and the last 2 in healing. 
The lymph nodes show an enlargement on the fourth day of the 
disease and are always markedly enlarged on the fifth. They decrease 
in size during the crusting of the primary lesion, but they are firmer than 
normal for a considerable time after the healing of the process. 
The constitutional reaction occurs at about the height of the active 
phase of the primary lesion—that is, on the sixth and seventh day of the 
disease. In a great majority of cases the temperature reaction begins 
on the sixth day of the disease and persists for 2 or 3 days. It is 
difficult to say just how long the fever lasts, as the decline is by lysis, but 
it is almost always within normal limits by the twelfth day. 
