305 
Six days. The nose presents an opaque area on the septum surrounded by a 
bright red areola. The lip is much swollen and the lesion shows an area of 
erosion surrounded by a ragged edge of elevated and hyperemic mucous membrane. 
The lesions on the palate have increased somewhat in size and show a distinct red 
areola. Body temperature 40°.2 C. 
Seven days. Considerable mucopurulent discharge from the nostril; swelling 
of the mucous membrane prevents inspection. Lesion on lip as before. The 
palate shows some increase in the size of the lesion. Body temperature 40° C, 
Eight days. The swelling of the mucous membrane in the nose continues. 
On the lip the lesion presents as an ulceration with marked inflammatory reaction 
about it. On the palate the lesion shows no erosion and has ceased to spread. 
Body temperature 40°.4 C. 
Nine days. Lesions as described yesterday. A general exanthem was carefully 
searched for but not found. Animal killed and autopsy done at once. No macro- 
scopic evidence of disease except at the sites of inoculation. 
No. 126. Half-grown male, Macacus cynomologus. Inoculated in the same way 
and with the same virus as the preceding animal. Body temperature 39° C, 
After 24 hours the nose shows a delicate crust on a slightly elevated area of 
mucous membrane. On the lip a small lacerated wound marks the point of 
inoculation. The palate. presents some reddening of the mucosa about the 
scratch. Body temperature 38°. C. 
Forty-eight hours. Lesions as above described. Body temperature 39° C, 
Three days. In the nose the elevation about the crust has increased. The lip 
shows an elevated, opaque, white area, 3 X 4 millimeters, surrounded by a diffuse 
red flush. On the palate is a slightly elevated grayish area, 2 X 4 millimeters 
in extent, surrounded by hyperemic mucosa. Body temperature 40°.4 C. 
Four days. Nose as before, save that the elevation has taken on a gray tint. 
The lip presents a macerated appearance over the area occupied by the lesion. 
The lesion on the palate has increasd in size. Body temperature 40°.5 C. 
Five days. On the palate the lesion is eroded, otherwise there is no change. 
Body temperature 39°.5 C. 
Six days. The nose presents a narrow crust on a pink elevation. The lesion 
on the lip shows signs of healing. Palate as before. The top of the tongue 
near its tip presents a gray elevated area, 2 millimeters across, surrounded by a 
pink areola. Lesions show no change since yesterday. Animal killed and 
autopsy at once made. Viscera show no macroscopic lesions. A single small 
vesicle outside the left eye is shown to be specific by microscopic examination. 
No other exanthem found. 
No. 127. Young female, Macacus cynomologus. Inoculated in the same way and 
with the same virus as the preceding monkeys. Body temperature 39°.2 ©. 
Twenty-four hours after. Slight elevation and reddening at the points of in- 
oculation. Body temperature 38° C. 
Forty-eight hours. In the nose there is reddening of the mucosa on the 
septum. On the lip a yellow line surrounded by slightly elevated and pink 
mucosa marks the site of inoculation. Palate negative. Body temperature 39° C. 
Three days. Nose negative. Lip shows a gray line on a white elevated area 
2.5 X 5 millimeters, the edge of which is translucent. Palate presents a grayish- 
white line 3 millimeters long. Body temperature 39°.5 C. 
Four days. Nose negative. The lip shows a gray-white area, 2 X 5 milli- 
meters, with a pink edge and a granular surface. Palate as before. Body tem- 
perature 39°.5 C. 
Five days. Nose negative. The lip is swollen and presents an erosion with 
a yellow surface and a thickened, pink edge 2 X 4 millimeters in extent. Palate 
