306 
presents an eroded area 2 X 5 millimeters, with a slightly depressed gray base 
and an elevated margin which is surrounded by reddened mucosa. Body tem- 
perature 38°.5 C. 
Six days. Lesions as before but somewhat increased in size. Body tempera- 
ture 39°.5 C, 
Seven days. Nose presents a narrow crust about the orifice of the left nostril. 
The lip shows a large erosion 1 centimeter across, the base of which is covered 
by yellow, macerated material and is surrounded by an elevated, ragged, pink 
border. Lesion on palate has increased in size. Body temperature 38°.8 C. 
Eight days. Nose shows an eroded area extending from the septum out upon 
the surrounding skin. Lesion on lip as before. Palate presents a long, narrow 
ulceration 2 8 millimeters in extent, with a white, elevated edge, and surrounded 
by a red areola. One small, pink, papular elevation on the inner side of each 
thigh and on right arm. Histological examination shows this lesion to be 
variolous. Body temperature 38°.5 C. 
Animal killed; at autopsy organs appear normal. 
No. 128. Full grown female, Macacus cynomologus. Inoculated in the same way 
and with the same virus as the preceding monkeys. Body temperature 39° C. 
After 24 hours there is slight reddening of the mucosa about the scratches. 
Body temperature 38°.2 C. 
Forty-eight hours. Lesions as before. Body temperature 38°.2 C. 
Three days. The lip is swollen and presents a white area, 1 by 3 millimeters, 
slightly elevated and surrounded by a pink areola. Palate presents 2 yellow ele- 
vations 2 by 4 millimeters in extent with a red periphery. Body temperature 
39°.5 C. 
Four days. Lesion on lip is excoriated. Palate as before, but lesion has 
spread somewhat. Body temperature 39° C. 
Five days. Lip shows an eroded area with a gray base and a white, elevated 
edge, surrounded by reddened mucous membrane. ‘The whole lower lip distinetly 
swollen and indurated. Palate as before. Body temperature 38°.2 C. 
Six days. Swelling of the lip more marked, The base of the lesion is yellow 
and the edge ragged. A minute, pink papular elevation appears on the gum op- 
posite the lesion. Probably an auto-inoculation, Palate as before. Body tem- 
perature 39° C. 
Seven days. Lesions as described but somewhat increased in extent. Body 
temperature 38°.5 C. ; 
Kight days. From this time on the primary lesions healed without complica- 
tion. A general exanthem was not found either before or after this date. Body 
temperature 37°.5 C. 
No. 129. Full grown male, Macacus cynomologus. Inoculated in the same way 
and with the same virus as the preceding animals. Body temperature 38°.5 C. 
Twenty-four hours after inoculation the lip and palate show a white line sur- 
rounded by hyperemic mucosa. Nose negative. Body temperature 39°.8 C. 
Forty-eight hours. Lip and palate show irregular elevation with opacity and 
and a peripheral flush at the site of inoculation. Nose negative. Body temper- 
ature 38°.2 C. 
Three days. Lip presents a yellow, eroded area, 2 by 5 millimeters, surrounded 
by a pink areola. Palate shows an opaque, white area, 2 by 5 millimeters, sur- 
rounded by reddened mucosa, Body temperature 39° C. 
Five days. Lesions on lip and palate somewhat increased in extent. The inoc- 
ulation in the nose evidently did not take. Body temperature 39°.4 Cc, Animal 
killed and autopsied at once. Viscera, present no macroscopic lesions. 
