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A series of 10 monkeys were inoculated on the palate alone and a series of 9 
upon the nasal mucosa alone. The results of the inoculations were similar to 
the experiments detailed above. 
SUMMARY. 
The lesion which develops on the inner side of the lip of the monkey 
following inoculation with vesicle contents presents the following macro- 
scopic characters. 
After 24 hours the site of inoculation shows, at most, a slight redden- 
ing of the mucous membrane about the scratch. 
After 2 days a narrow, white line is seen, which is surrounded by a- 
faint, red flush. 
After 3 days there is a definite, opaque, white, area, 2 or more milli- 
meters in extent, slightly elevated above the general surface. This area 
is more or less eroded and is surrounded by a distinct zone of hyperemic 
mucous membrane. 
After 4 days the opaque area is somewhat eroded and presents a 
shallow ulcer with an elevated, white, often sinous, edge, which is 
bordered externally by reddened mucosa. 
From this time on the lesion presents the same characteristics, the only 
change being due to a gradual extension of the process. After 8 or 9 
days the peripheral flush fades and healing begins. This process results 
in complete repair after about a week. 
Inoculation of the palate causes a lesion similar to that following 
inoculation of the lip, and the lesion runs essentially the same course. 
In this situation the lesion is less apt to become eroded. 
After inoculation of the mucous membrane of the nose it is difficult 
to follow the process from day to day, as at the time when the lesion is 
undergoing its active evolution the swelling of the mucous membrane 
which accompanies the process prevents inspection during life. From 
study of the site of inoculation in animals killed at various periods it is 
seen that the evolution of the’ lesion in the nose differs principally from 
those on the lip and palate in that there is less tendency to form an ulcer. 
When the inoculation is near the anterior nares the process tends to 
spread out on the skin about the nostril and then takes on the character- 
istics of a skin inoculation. 
No notable constitutional reaction followed the inoculation of the 
mucous membrane. The temperature reaction was indefinite. A gen- 
eral exanthem was observed in 2 of the monkeys. 
Histology of the primary lesion.—Lip: Sections from lesions collected 
25 and 53 hours after inoculation show no evidence of a specific process. 
The defect in the epithelium caused by the inoculation has completely 
been repaired, and the only evidence of the wound is a small collection 
of fibrin and polynuclear leucocytes just beneath the epithelium, 
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