328 
No. 109. The first, second, third, fourth, and sixth vaccinations were positive, 
while no reaction followed those on the fifth, seventh, eighth, and ninth days of 
the experiment. 
No. 110. The first to the fifth vaccinations, inclusive, resulted positively, while 
those on the 4 succeeding days were not followed by a reaction. 
No. lll. The first to the fifth vaccinations, inclusive, yielded a typical vaccine 
process, while the remaining 4 were without result. 
No. 112. The first, second, and third vaccinations were negative, the fourth was 
abortive, and the fifth, sixth, seventh, eighth and ninth were negative. 
(b) Daily inoculation of the skin with variola virus.—Eight monkeys (M. 
cynomologus) were used in this series of experiments. Each animal daily re- 
ceived a single inoculation with variola virus. Variola virus No. 167 (vesicle 
contents), No. 199, or No. 200 was employed, and after the final inoculation the 
sample was tested by inoculation upon the skin of a fresh monkey and shown 
still to be potent. 
No. 136. The inoculations on the first, second, third, fourth, and fifth days of 
the experiment yielded typical lesions. The fifth, sixth, and seventh inoculations 
were not followed by a lesion. A general exanthem developed on the ninth day 
of the experiment. — 
No. 137. The first to the fourth inoculations, inclusive, were positive, while 
the remainder were negative. An exanthem appeared on the ninth day. 
No. 138. The first 4 inoculations were positive, which the last 3 were negative. 
An exanthem developed on the eighth and ninth days. 
No. 213. The first, second, third, and fourth inoculations were positive, while 
the fifth, sixth, and seventh were negative. On the seventh, eighth, and ninth 
days a general exanthem was observed. 
No. 214. The inoculations on the second and third days yielded positive, those 
on the first and fourth abortive, and those on the fifth, sixth, and seventh negative 
reactions. No general exanthem developed. 
No. 215. The first four inoculations were positive, the fifth was questionable, 
the sixth and seventh were negative. No exanthem developed. 
No. 116. The first, second and third inoculations were positive, the fourth was 
questionable, the fifth, sixth, and seventh were negative. A general exanthem 
appeared on the eighth and ninth days. 
No. 117. The first four inoculations were positive, the fifth was questionable, the 
sixth and seventh were negative. An exanthem appeared on the ninth day. 
(c) Simultaneous inoculation with vaccine and variola virus.—Five monkeys 
were selected and inoculated on the left groin with vaccine virus No. 1, and on 
the right side of the chest with variola virus No. 200. 
Four animals reacted typically to both inoculations and 2 of these developed 
an exanthem on the ninth day of the experiment. The fifth monkey reacted 
typically to the vaccine virus, but did not show a process at the site of the 
inoculation with variola virus or develop an exanthem. 
