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their substance. Intranuclear forms of cytorcytes were found in vario- 
lations of the skin from 3 to 8 days after inoculation. As they were so 
uncertain in their occurrence one could not well judge at what time they 
were most numerous. In all cases they were preceded by the cytoplasmic 
forms and were never found without these. 
In primary variola lesions of the orang-utan taken 6, 7, and 8 days 
after inoculation, nuclear forms are very abundant. A variety of both 
the specific forms and the nonspecific reticular and hyaline bodies may 
be found in a single section. In this respect the skin variolations in 
the orang-utan differ greatly from those of the two species of monkey 
employed, which show relatively few nuclear forms. Cytoplasmic forms 
are present in these variola lesions of the orang-utan. Their distribution 
is similar to that in the preceding species. 
In the lesions following variolation of the monkey’s cornea the cyto- 
plasmic forms are constantly present but never the nuclear forms. The 
cytoplasmic forms appear rather more numerous than in vaccinations of 
the cornea, probably on account of the retention of the epithelium. They 
are found in lesions of 24 hours after inoculation and are present in those 
of 11 days’ duration, beyond which time we have no material. This non- 
occurrence of intranuclear forms is probably due to physical conditions. 
In the primary inoculations of the lip, the nose, and the palate the oc- 
currence and distribution of both cytoplasmic and nuclear forms are 
essentially the same as those found in skin variolations. In one instance 
the nuclei of the nose lesion were filled with the nonspecific eosin-staining 
inclusions, but there were but few typical intranuclear bodies. 
In lesions of the trachea produced by inoculation with variola virus 
cytoplasmic forms are present. In one case a specific variolous pneu- 
monia accompanied the inoculation of the trachea and cytoryctes were 
present within the epithelial cells lining the alveoli. In this case the 
process appears to have extended from the bronchus into the lung sub- 
stance. 
THE OCCURRENCE OF CYTORYCTES VARIOLA IN EXANTHEM LESIONS. 
A general eruption followed the inoculation of various sites upon the 
body with variola virus. Eruptions were produced by the inoculation 
of the skin, the cornea, the mucous membrane of the lip, nose, and palate, 
the trachea, and by intravenous injection of variola virus. The lesions 
of the eruption appear after periods of from 6 to 10 days subsequent to 
inoculation. 
Cytoplasmic forms are found constantly in these eruption lesions, 
excepting in those in which repair is advanced. Except in the exanthem 
resulting from intravenous injection, the specific nuclear forms are 
rare. However, they are found in the exanthem following skin inocula- 
tion in several cases, and it is probable that by a study of a greater 
number of lesions and a longer series of sections they would be shown 
to occur in a large number of cases. The exanthem following intravenous 
