“a CLF 
340 
with subsequent amputation of the tail proximal to the point of inocula- 
tion. This eruption resembles in this, as well as in other respects, the 
eruption of variola vera in man. 
(5) The cytoplasmic forms of cytoryctes are constantly associated 
with variola and vaccinia in whatever portion of the body the lesions 
may develop. Thus they are found included in a variety of cells, the 
squamous epithelium of the skin, the cornea, the mucous membrane of 
the nose, oral cavity, and cesophagus, the cells of the sebaceous and 
Meibomian glands, the epithelium of the conjunctiva, the columnar 
epithelium of the nose, trachea, and seminal vesicle, the epithelium 
lining the alveoli of the lung, endothelial cells, and connective-tissue 
cells. 
(6) The occurrence of cytoryctes in the cells of the corium, and 
‘especially within the endothelium of vessels, suggests a possible method 
of dissemination of the organism in the production of the exanthem. 
However, endothelial cells containing cytoryctes were also found in a 
few instances in vaccine lesions, a form of the disease never accompanied 
by a general eruption. 
(7) The occurrence and distribution of the specific inclusions is best 
explained by the hypothesis that they are parasites, and that as such they 
are the cause of the disease. 
; REFERENCES. 
(1) Carxins, G. N., 1904. The life history of Cytoryctes variole Guarnieri. 
Journal of Medical Research (1904), XI, 136. 
(2) CouncitMAN, MAgratn, and BrrncKkerHorr, 1903. A preliminary communi- 
cation on the etiology of variola. Journal of Medical Research (1904), 
A,B 12. 
(3) CouncitMAN, MaaratH, and BRINCKERHOFF, 1904. The pathological anat- 
omy and histology of variola. Journal of Medical Research (1904), XI, 
12. 
(4) Bose, F. J. Le parasite de la vaccine. Compt rend. Soc. Biol. (1903), 
LV, 1178. 
(5) Bosc, F. J. Le parasite de la variola. Compt. rend. Soc. Biol. (1903), 
LV, 1204. 
(6) Davipson, ©. Tédlich verlaufender Pockenfall. Berliner klin. Wochensch. 
(1905), XLV, 635. 
(7) Ewrna, J., 1904. Comparative histology of Vaccinia and Variola. Journal 
of Medical Research (1904), XII, 511. 
(8) Ewine, J., 1905. The structure of vaccine bodies in isolated cells. Journal 
of Medical Research (1905), XIIT, 233. 
(9) Howarp, W. T., and Perkins, R. G. A study of the etiology of variola. 
Journal of Medical Research (1904), XII, 360. ' 
(10) Magrati and BRINCKERHOFF, 1904. On the occurrence of Cytoryctes vario- 
lw, Guarnieri, in the skin of the monkey inoculated with variola virus. 
Journal of Medical Research (1904), XI, 173. 
(11) Scurumer, P. Ueber die als Protozoan beschriebenen Zellenschliisse bei 
Variola. VWirchow’s Arch. (1905), CLXXIX, 461. 
(12) Srecet, J. Untersuchungen tiber die Aetiologie der Pocken und der Maul- 
und Klauenseuche. Verlag der Kénigl. Akadamie der Wissenschaften, 
Berlin (1905). 
