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ILLUSTRATIONS. 
PLATE I. 
Variola inoculata in the orang-utan (Simia satyrus). Lesion at the site 
of inoculation. Duration 6 days. Wide spread vesicle formation ex- 
tending outward from the inoculation wound. 
. Variola inoculata in the orang-utan (Simia satyrus). Lesion at the site 
fod 
of inoculation. Duration 7 days. Vesicle contains more fluid than 
before. Multilocular character of lesion well shown. False vesicle 
formation to the right of the inoculation wound. 
PLATE II. 
Variola inoculata in the Philippine monkey (Macacus cynomologus). 
Lesion at the site of inoculation. Duration 6 days. Dark mass in 
center is the crust. On either side there is vesicle formation and at 
the periphery of the lesion thickening of the epidermis. Marked edema 
and cellular infiltration of the corium beneath the lesion. 
. Variola inoculata in the Philippine monkey (M. cynomologus). Lesion 
of the exanthem in the skin of the palm of the hand. The lesion is 
well advanced in the process of healing. 
Puate IIT. 
Variola inoculata in the Philippine monkey (M. eynomologus). Lesion 
of the exanthem. Vesicular stage. Well-marked cellular infiltration 
about the vessels of the corium. 
. Variola inoculata in the Philippine monkey (M. cynomologus). Lesion of 
the exanthem. Pustular stage. 
Priate IV. 
Variola inoculata in the Philippine monkey (M. eynomologus). Lesion of 
the exanthem in cheek pouch. Animal was inoculated in the trachea. 
. Variola inoculata in the Philippine monkey (M. cynomologus). Focal 
lesion in the seminal vesicle, of the nature of an exanthem. From same 
animal as in fig. 1. 
PLATE V. 
Variola inoculata in the Philippine monkey (M. cynomologus). Lesion at 
the site of inoculation in the nose. The process in a stratified 
epithelium. 
. Same as fig. 1, but inoculation is on a columnar epithelium. Note the 
cellular infiltration of the submucous tissue. 
346 
