555 
changes were evidently caused by masses of bacteria growing in the 
tissue of the cornea. | 
Grouping this latter series of inoculations with those previously done, 
there were in all nine rabbits inoculated upon the cornea with the vesicle 
contents of varicella. Of these, five were inoculated with the clear, fluid 
exudate, two with the clouded fluid, and two with the semi-fluid pus; the 
latter material came from cases which, although at first considered doubt- 
ful, were unquestionably varicella as was proved by further observations. 
In no case was the inoculation followed by any specific process. Three 
monkeys were inoculated upon the skin, one with clear fluid, and two with 
semi-fluid pus from varicella lesions; all gave negative results. Thus, up_ 
to the present time it has not been possible to produce any form of the 
disease in animals by the inoculation of vesicle contents of varicella. 
Although the data furnished by the inoculation of three monkeys is 
meager, yet the results stand in marked contrast to those obtained through 
the inoculation of monkeys with variola virus. 
Further study was directed to the pathological process concerned in 
the varicella eruption. As previously stated a study was made of thirty- 
eight cases and attention was paid to the development of the eruption and 
the general condition of the patient. A more critical study with daily 
observations was made of eleven of the more favorable cases. These were 
selected because they were seen soon after the first appearance of the 
eruption and were uncomplicated by the appearance of skin lesions other 
than varicella. 
Concerning the clinical features of the disease there was nothing 
presented more than may be found in the text-book descriptions. The 
cases were usually discovered within twenty-four hours after the appear- 
ance of the eruption. In some of the severe cases there was considerable 
fever and constitutional disturbance, but in the majority there was no com- 
plaint of feeling ill. All degrees of severity were represented from 
mild cases in which there were not over a dozen lesions in the entire 
course.of the disease to severe ones in which the lesions were thickly 
sprinkled over the entire surface of the body. Lesions were present in 
either the palms of the hands or the soles of the feet in twenty-seven of 
the thirty-eight cases. The following case is given in order to convey 
an idea of the character of the disease. 
Case No. 8—Adult male Filipino seen on June 2, Eruption appeared within 
last twenty-four hours. Feels rather ill. He presents two good scars from 
former vaccination. An eruption scattered over trunk, arms, and legs, with only 
three lesions on face, consists of vesicles and small red macules. The vesicles are 
oval or hemispherical, superficial, tense, contain clear fluid, and are situated upon 
a reddened area of skin. The larger vesicles measure about 5 mm., the smaller 
ones are barely discernible. They are easily ruptured. The macules consist of 
small, reddened areas of the skin, in some cases slightly elevated but barely 
palpable. In some such areas there is a minute central vesicle, in others the 
center is a rough, slightly granular elevation. Certain lesions were marked for 
future observation. 
Oi oo AS ee 
