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Prate III, 
15. A vesicle of six days duration. A break has occurred in the lateral wall 
of the vesicle at some time during its development allowing the fluid to 
penetrate and separate the horny layers. A coil gland duct extends 
down from the floor of the vesicle. Repair is well advanced and the 
epithelium is growing over the defect upon which the vesicle is 
situated. 
16. A minute “dry” lesion showing advanced degeneration of the epithelial 
cells without any appreciable fluid exudate. 
17. Multinueclear epithelial cells shown at lower magnification in Fig. 4. 
Outline irregular, without definite cell membrane; cytoplasm presents 
a loose reticulum; nuclei hollow, with chromatin situated near nuclear 
membrane, and usually containing the specific inclusions. 
18. Cells, probably endothelial in origin, situated in corium. They show 
localized swelling of the nucleus about the specifie inclusions. 
19. An atypical vesicle, multilocular in type and showing a central crust. 
The base is infiltrated with leucocytes. 
PLATE IV. 
(Camera lucida drawings with Zeiss compensation ocular No. 6; objective, 2 millimeters; 
aperture, 1.30.] 
20. Tissue about a small blood vessel of the corium just beneath an early 
varicella vesicle. An endothelial cell in situ upon the vessel wall con- 
tains a small inclusion within its nucleus. Other nuclei in the tissue 
about the vessel contain the characteristic red staining inclusion 
situated in clear spaces or vacuoles in the nucleus. 
21. Skin excised early in the disease. The epidermis of the Filipino con- 
‘tains a large amount of pigment, A single endothelial cell containing 
a nuclear inclusion is shown. Another endothelial cell found in an- 
other optical plane and also containing a nuclear inclusion is not shown. 
The epithelial cell above shows a characteristic nuclear inclusion. The 
study of serial sections failed to show any other similarly affected cells 
in this portion of the epidermis so that it is to be regarded as a very 
minute lesion, 
22. Nuclear and cytoplasmic inclusions in the cells of both corium and 
epidermis. 
23. An epithelial cell possessing two nuclei, one of which appears hollow and 
contains a red stained body. Just outside the nuclear membrane is a 
more intensely stained body. 
24. Epidermal cells in the fioor of developing vesicle. Amitic nuclear division 
has here resulted in a large multinuclear cell containing inclusions in 
several of its nuclei, and also one extra nuclear inclusion. Other 
inclusions are present in adjacent cells. Some of these inclusions, 
especially the cytoplasmic, have deeply stained central points. 
25. Cells from a sebaceous gland through which the knife passed in excision. 
Many of the nuclei containing inclusions have been ruptured. The 
inclusions are relatively large and show in certain instances a sugges- 
tion of reticular or vacuolar structure. The deeply stained granules 
present in two may possibly be superimposed or included chromatin 
from the cell nucleus. 
26. An epidermal cell from a varicella vesicle showing the extension of a 
portion of the specific nuclear inclusion through the nuclear membrane. 
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