20, 6 : Garcia and Guevara: Datura alba 601 
TABLE 1.—Symptoms produced by Datura alba in a male dog weighing 
4.5 kilograms. 
[Date of experiment, January 25, 1921.] 
os Pulse | piam- ; Mucosa. | 
Time. tion per ae eter of Remarks. 
min- | ‘ute, | Pupil. i ; A 
ute. Conjunctiva./ Lingual. Nasal. 
a.m. p.m. mm. . , 
9. 48 30 90 4| Moist______. Moist-_-..... Moist. 3.252 Quiet. 
9.53 30; 84 Ce pear BO nists aad Oe ik 2 Do. 
10. 02 ceteris: peatatalaeral peasairaten Geri manent Cae eee ere ne Two mils of 
aqueous prep- 
aration per 
kilogram in- 
jected hypo- 
dermically. 
10. 04 82 168 12 | Moist. _..... Moist______. Moist _._.__. Cried whenever 
touched. 
10.09 42 168 a) ebonats OO ie ceo OO accuse: Bees Slightly _rest- 
: less. 
10.14 50 186 2 tT Desa, BB yn Seen racist fa eee Bee Restless. 
10, 29 54 192 pT eae MG ieee tec se fennel eee! 0G ciicuss Ataxic gait. 
10. 50 48 186 182-255 WG cuties ceca ts hati) irene rs Eee ac Barked fre- 
quently; 
sought dark 
place, 
11,00 42 168 12 oie rss paeenterend sae cs are way eee C6, Quiet; lying 
5 down. 
11,15 30 144 424 ce 06 core (1 C Sepesne dl eee do ..._..| Drowsy. 
11.35 30 138 | St ee pT enor Renee do eee] Asleep. 
1.00 30 144 Er fs Petipa OG colic Ci Me pate Bene ee (Prag hietades Stood with dif- 
ficulty when 
made to do so; 
swayed to and 
fro and from 
side to side. 
2.00 188 fe dos Fe do do Fast asleep. 
3.00 24 128 ob id Bee CF pM cote oer ae Pcs Ss Do. 
3.30 128 sy fd bee 72 OG Cocco s do do | Unable to walk. 
ACTION ON THE CIRCULATION AND RESPIRATION 
We studied under this heading the effect of Datura alba on 
the heart rate, the blood pressure, and the respiration. The 
blood pressure was recorded with a mercury manometer; the 
respiratory movement with Gunn’s stetograph,(7) and the heart 
rate with a tambour connected with blood-pressure connection. 
Table 2 records the result of one experiment on a dog weighing 
6.7 kilograms, which was anesthetized with morphine and 
chloretone. 
Table 2 shows that soon after intravenous injection of the 
aqueous Datura alba preparation the heart rate was increased 
