608 The Philippine Journal of Science 
2. The respiration was increased in dogs and cats after large 
doses, probably through stimulation of the respiratory center. 
3. It dilates the pupils by peripheral action. The most prob- 
able action in this case is paralysis of the oculomotor nerve end- 
ing or its myoneural junction. 
4. It stops the secretion of the submaxillary gland produced 
by pilocarpine. Since the glands were not paralyzed, the site of 
action must be either the nerve ending or the myoneural junction 
which is stimulated by pilocarpine. 
5. The endings of the vagus nerves are depressed by small 
doses and completely paralyzed by slightly larger doses. The 
increased heart rate, slight rise of blood pressure, and decreased 
pulse pressure can be explained by diminished tonus of the vagus 
nerves. 
6. It tends to stop intestinal contraction by peripheral action, 
for this was obtained in isolated intestine. 
7. The alkaloidal content of Datura alba seeds as assayed 
biologically, using atropine or hyoscine as standard, is 0.5 per 
cent. 
8. The tentative therapeutic doses of Datura alba seeds that 
may be recommended for man are from 0.06 to 0.12 gram and 
of the fluidextract from 1 to 2 drops. 
REFERENCES 
. Bacon, R. F. Philip. Journ. Sci. 1 (1906) 1020. 
. BowMAN, F. B. Bull. Manila Med. Soc. 3 (1911) 1. 
BRILL, HARVEY C. Philip. Journ. Sci. § A 11 (1916) 257. 
BROWNE, FRANK. Pharm. Journ. IV 3 (1896) 197. 
. CUSHNY, ARTHUR R. A Text book of Pharmacology and Therapeutics. 
Lea and Febiger, Philadelphia and New York, ed. 7 (1918) 341. 
. ForD, CHARLES, Ho-KAI, and Crow, W.I. Pharm. Journ. III 18 GESY) 
320. 
. GUNN, J. A. Journ. Physiol: 52 (1918) 29. 
Hesse, O. Pharm. Journ. IV 10 (1900) 252. 
MERRILL, ELMER D. Philip. Journ. Sci. § C 7 (1912) 166. 
Muxopapya, G. M. Indian Med. Gaz. Calcutta 48 (1913) 312. 
SOLLMANN, ToRALD. A Laboratory Guide in Pharmacology. W. B. Saun- 
ders Co., Philadelphia and London (1917) 203. 
12. SOLLMANN, ToraLp. A Manual of Pharmacology. W. B. Saunders Co., 
Philadelphia and London (1918) 267. 
13. TAvera, T, H. Parpo pg. The Medicinal Plants of the Philippines. 
Translated and revised by J. B. Thomas, P. Blakiston’s Son and Co., 
Philadelphia (1901) 179. 
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