= ‘Sy se liealilll eal’ ih or Sian lial nse alll 
584 
either from the waste substances of the body or from mixtures of nutrient 
materials. [ experimented unsuccessfully with media composed — to 
resemble the soil in their chemical constituents; neither was [ successful 
in cultivating an organism capable of causing rinderpest in media con- 
taining bile, blood, lecithin, cholesterin, nucleo-proteids, ete. 
SYMPTOMS. 
The first apparent symptom of the disease is a rapid rise of temper- 
ature, after an incubation period of from three to six days. (Chart 4, 
No. 904.) This rise almost invariably appears between twenty-four 
to thirty-six hours before any other symptom is apparent. (Chart 8, 
No. 1.) The next one, at least in animals from the Philippines, is an 
injection of the conjunctive which is immediately followed by a profuse, 
sero-purulent discharge from the eves, often so irritating as to produce 
excoriation in its course across the face. A yarying degree of salivation 
is also observed, but in Manila, ulcers of the mouth or lips are rarely 
seen, There is a somewhat profuse, fetid discharge from the nose. 
With the onset of these symptoms, the appetite diminishes and is finally 
completely lost; rumination ceases and a rapid diminution in weight 
follows; the coat is staring. The beginning of the diarrhoea varies: 
it may be either early or late in the disease ; in the usual course it becomes 
muco-sanguinous, whereas the less virulent forms may run their course 
almost to the end with no more than an ordinary, very fluid diarrhoea. 
A peculiar odor of the intestinal discharges is almost characteristic of 
rinderpest. When the disease is virulent, tenesmus becomes marked 
and as a result, prolapsus of the rectum is of not uncommon occurrence. 
Death occurs in collapse, following a fall of temperature; it usually takes 
place between the sixth and eleventh days of the disease. (See cases, 
Chart 8, No. 1, and Chart 9, No. 3.) 
Abortion follows with regularity in the case of pregnant animals and 
lactation ceases in milch cows. 
The natural disease in Philippine native, non-immune cattle either 
may show a gradually rising temperature, which reaches its maximum 
on the second or third day; or a rapid rise to a maximum which is per- 
sistent, with the exception of the morning fall, until the lethal drop: 
or again a sudden advance, followed by a fall and a normal subsequent 
temperature or, indeed, no well-marked rise at all. So far as our obser- 
vation goes, there has been no case of the natural disease without 
diarrhoea, which usually occurs between the fourth and sixth days. 
The usual experience with the disease which is artificially produced 
is a well-marked reaction. However, in some instances this has either 
been very moderate or even scarcely perceptible; in a few there has been 
a gradual, rising reaction and in but one or two a sudden, moderate 
