585 
advance followed by as rapid a fall, after which the temperature only 
varied within normal limits until it showed the quick, lethal depression. 
In one such case, no diarrheea occurred, although an autopsy conclusively 
demonstrated rinderpest to be present. 
Our observations in general may be condensed as follows: 
(a) In native, susceptible animals pastured on infected ground, rin- 
derpest may appear at any time between the fifth and twenty-third days. 
(Chart 10, No. 839.) 
(6) After inoculation with virulent blood, the disease appears between 
the third and fourth days. (Chart 11, No. 932.) 
(¢) Diarrhea becomes evident between the fourth and sixth days 
after the onset of the fever. (Chart 11, 932.) 
(d) The temperature may vary between 39°.4 and 41°.8. 
(¢) Death is preceded by an abrupt fall of temperature and occurs 
six to nine days after the reaction. (Chart 10, No. 839.) 
MORBID ANATOMY. 
There is some difference of opinion in regard to the characteristic 
lesions of this disease. The European, South African, and Philippine 
types of rinderpest differ in many points; perhaps it is true that none 
of the morbid changes are constant and that they may vary in different 
countries, epidemics, and animals (Walley). 
The most constant alterations in the body are emaciation, sero-purulent. con- 
junctivitis, congestion, and general inflammation or ulceration of the gastro- 
intestinal tract, the latter changes being especially localized in the fourth stomach 
and pylorus ; however, the mucous membrane of the fourth stomach and of the large 
and small intestine may simply show a diffuse reddening at the summits of the 
folds, Petechia are encountered not only in the gastro-intestinal epithelium but 
also in the heart, kidneys, liver, and lymphatic glands. Often, the only demon- 
strable lesions may be those of the fourth stomach, pylorus, and upper part of 
the small intestine. 
In the Philippine Islands, as Jobling has mentioned, we rarely, if 
ever, encounter the classical cutaneous eruption described in the Euro- 
pean disease; it is also true that ulcerations of the nasal and oral mu- 
cous membrane are rare, as are those of the patches of Peyer. In place 
of this condition, a congestion is present in most cases. 
The gall bladder is usually distended and contains a thin, greenish 
bile. The vagina is always congested and the urinary bladder oe- 
casionally presents a similar condition. 
There are also no discoverable changes in the blood, unless, perhaps, 
there is a leucopenia of mild degree. In cases in which diarrha@a is 
severe it is certain that a general concentration exists, and in at least 
some instances there is not only a relative but also an absolute diminu- 
tion in the number of white blood cells. The following figures, which 
