THE PHILIPPINE 
JOURNAL OF SCIENCE 
VOL. 21 JULY, 1922 No. 1 
MANUFACTURE OF CERTAIN DRUGS FOR THE 
TREATMENT OF LEPROSY ' 
By GRANVILLE A. PERKINS 
Chemist, Bureau of Science, Manila 
ONE PLATE 
The chemical investigation of leprosy drugs by the Bureau of 
Science ? has been continued since Brill’s latest paper, especially 
since May, 1920, when the work was placed in the hands of 
the Committee on Leprosy Investigation, a joint committee of 
the Philippine Health Service, the University of the Philippines, 
and the Bureau of Science. Since that time the Bureau of 
Science has prepared a number of drugs, which were used ex- 
perimentally at San Lazaro Hospital and Culion Leper Colony. 
Practically all of these have been found to be beneficial, in vary- 
ing degrees. The report of this work from the medical point 
of view, including the methods of administration and observed 
effects, will be published by the committee. The present paper 
is written from the chemist’s standpoint, and takes up the 
preparation and chemical composition of the drugs used. 
The treatment of leprosy in recent years has tended away 
from the old methods of oral administration and inunction 
toward the injection method, both intramuscular and intra- 
venous. Although the manner of application has changed, the 
* Received for publication January 28, 1922. 
* Brill, H. C., Hydnocarpus venenata Gaertner; false chaulmoogra, 
- Philip. Journ. Sci. § A 11 (1916) 75; A chemical investigation of the 
seeds of Pangium edule and of Hydnocarpus alcalae, ibid. § A 12 (1917) 
37; Brill, H. C., and Williams, R. R., The use of chaulmoogra oil as a 
specific for leprosy, ibid. § A 12 (1917) 207. 
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