12 The Philippine Journal of Science 1922 
Sodium gynocardate A is used in the form of 3 per cent 
sterilized solution, containing 0.5 per cent phenol, and 0.5 per 
cent sodium citrate to avoid clotting. 
SODIUM GYNOCARDATE §S 
This preparation was made in the same manner as sodium 
gynocardate A, except that the total fatty acids instead of 
the crystallized acids were employed. As the preparation was 
found to be irritating, the committee soon decided to use in 
its place a similar solution (sodium gynocardate D) differing 
only in that the fatty acids have been purified by distillation 
in vacuum. The irritating substances are thus removed to a 
large extent. 
CHAULMOOGRA EMULSION 
About the time that Rogers was beginning the intravenous 
injection of chaulmoogra soap solutions, Vahram”*° was using 
a very fine emulsion of chaulmoogra oil in the same manner. 
A mixture of the oii with 20 parts by weight of acacia was 
desiccated to cause intimate union, and then mixed with 1,390 
parts of water, forming a very dilute emulsion. This prepara- 
tion is now on the market as “Collobiasis of Chaulmoogra,” 
made by the Laboratoires Pharmaceutiques de Dausse, Paris. 
This “Collobiasis” has been used by the Committee on Leprosy 
Investigation for direct infiltration in the lesions and, to a 
smaller extent, intravenously. A similar chaulmoogra emulsion, 
prepared at the Bureau of Science, has also been used for in- 
filtration. 
SODIUM MORRHUATE 
Cod-liver oil has not been used to any large extent in leprosy, 
but it has had wide application in the treatment of tuberculosis. 
It was probably for this reason that Rogers 2° chose cod-liver 
oil as a basis for a preparation similar to sodium gynocardate 
for use in tuberculosis. The new drug, which he named sodium 
morrhuate, has given good results in the treatment of this 
disease, and even better results in the treatment of leprosy. 
The composition of cod-liver oil is very complex. It contains 
glyceryl esters of the common fatty acids, palmitic, stearic, and 
oleic, together with a number of characteristic fish-oil acids 
*Vahram, M., Progrés Médical (1916) 19. New Orleans Med. and 
Surg. Journ. 69: 230. 
* Rogers, L., Ind. Med. Gaz. 53 (1918) 73. 
