950 The Philippine Journal of Science 1922 
The 26 children discharged for leprosy or suspicious signs of 
leprosy were repeatedly examined during the period from June, 
1921, to February, 1922, and 4 were found nonlepers, 11 showed 
suspicious signs of leprosy but were bacteriologically negative, 
and 11 were clinically and bacteriologically positive. A tabula- 
tion is given (Table 4) to show the age at which the suspicious 
or definite leprosy developed and the period of segregation before 
such development, that would indicate the minimum period of 
time at which a latent leprosy may manifest itself. 
Glancing over Table 4, one notices that children isolated at 
as early an age as one year (No. 12) developed later signs of 
leprosy confirmed by bacteriological examination; and that 
definite leprosy may appear within a period of between four 
months (No. 1) and three years and three months (No. 21) 
after isolation. The two cases transferred outside of Culion and 
later returned as positive probably developed the disease much 
earlier than the date of their return, as they no doubt escaped 
detection for a long time. Several months or years may elapse, 
therefore, after contact or association with lepers has ceased, 
before suspicious or definite signs of leprosy develop. 
INCIDENCE OF LEPROSY AMONG THE CHILDREN OF LEPERS 
Denney (2) has already published data regarding the incidence 
of leprosy among the children of lepers born in Culion. Our 
figures give the results of a general survey made in February 
and March, 1922, of all the children born and living in Culion 
up to December 31, 1921, and take into account other details 
not previously considered. The total number of children exam- 
ined was 308, of which 153 were males and 155 females. The 
results are shown in Table 5. Both parents of practically all 
the children examined were lepers. 
The children have been classified into positive lepers, clinical 
lepers, suspicious, and negatives or nonlepers. Positive lepers 
are those who -show definite clinical signs of leprosy and in 
whom Bacillus lepre has been demonstrated. Clinical lepers 
are those who are negative bacteriologically, but who show at 
least one of the following symptoms: (a) Anesthesia in the ulnar 
or peroneal region which cannot be attributed to other diseases ; 
or (b) whitish patches which show definite anzsthesia, either 
thermal only or both thermal and tactile; or reddish tint indica- 
tive of progressive changes; or which definitely show no sweat- 
ing on pilocarpine injection, in contrast with the surrounding 
normal skin and its corresponding symmetrical area on the other 
