19, 6 Lantin: Methods of Serum Application ' 639 
toms follows after the next day. The intravenous injection 
is usually followed by a chilly sensation which may last thirty 
minutes, and is accompanied by rise of temperature. 
Although I have observed no accident so far, such as sudden 
death following just after the intravenous injection, or symptoms 
of embolic formations, the possibility that such may occur 
under certain conditions should not be overlooked. The treat- 
ment should therefore be given with great prudence and caution. 
Day of disease. 
DG i RB id, pe Otte tM Oe Ae dd, A I ee 
4/ Patient "2 ee 50 
Intravenous |injections . Stbols — 
Serpe ere ate S| Temperature—-+ | 
SS TStST Sire itrsetTrese > 
a ay) Pe = N 
40 = t t t | T } ! 40 
My \ 
g \ R 
8 & L\ 4 
§ 39}— wt } \ 30 # 
s \ 
g \ ° 
a a ee nes 
oN tA 0 
5, TON \ 2 
EP 2 y 
°. ro% 
5 ‘3 = ° i 4 a 
rch nabs | wes iE | BAG § SP sik j 
37 No-|-? Bee \ 8-07 Nl 0 
\ 
 * ene es 
Fic. 6. Showing the effect of serum administered intravenously. Patient S. T. 
An example of the results of intravenous injection is seen in 
fig. 6. 
Aside from the specific action of the serum in the treatment 
of this disease, its nonspecific action should also be considered. 
When the serum is introduced into the body it may act as 
a foreign protein, stimulating the body to produce nonspecific 
Substances. The production of nonspecific substances as the 
result of the use of foreign protein has been considered seriously 
in the treatment of typhoid fever(6) and of arthritis.(7) In 
