A CASE OF ACUTE MANIA ASSOCIATED WITH 

 PLASMODIUM VIVAX INFECTION » 



By Frank G. Haughwout, Pedro T. Lantin, and Ricardo Fernandez 

 Of the University of the Philippines, and of the Philippine General Hospital 



ONE TEXT FIGURE 



The case cited here is deemed worthy of note because it is 

 one of the comparatively small number of cases recorded where 

 infection with Plasmodium vivax has been associated with cere- 

 bral symptoms and death. Parasites were present in the periph- 

 eral circulation in small numbers only and the temperature 

 of the patient at no. time rose higher than 39° C, that point 

 being reached a few hours before death. Prior to that time the 

 fever did not rise above 38° C, this elevation coming several 

 days after the onset of an acute mania. 



The patient? was one of a series of cases that was being ex- 

 perimentally treated with Roentgen rays for splenomegaly of 

 malarial origin, the results of which work will be reported in 

 another paper. He received only one irradiation, and that eight 

 days before the development of the mental disturbance which 

 ran its course and terminated in death eight days following its 

 onset. At no time did the patient show any indication of injury 

 that it seemed possible to trace to the Roentgen rays, and the 

 necropsy failed to reveal any such evidence. 



The subject was a male Filipino, 19 years old, unmarried, 

 and a waiter by occupation. He was born in Iloilo and had 

 resided in Manila for three months. About a year before his 

 admission to the Philippine General Hospital he had gone to 

 Davao where he had stayed for three months. During his stay 

 in that place he had chills, fever, and headache every day during 

 a period of almost two months. These symptoms recurred in- 

 termittently after his departure from Davao, and also continued 

 following his arrival in Manila. 



Physical examination made by Dr. Wenceslao Vitug of the 

 house staff, showed the patient to be a poorly developed, poorly 



1 Contribution from the departments of parasitology and medicine, Uni- 

 versity of the Philippines and Philippine General Hospital. 



563 



