A COMPARATIVE STUDY OF DIFFERENT METHODS OF 
TREATMENT OF TYPHOID FEVER* 
By Pepro T. LANTIN 
(From the Department of Medicine, College of Medicine and Surgery, 
University of the Philippines, and the Clinics of the Philippine General 
Hospital, Manila) 
TEN TEXT FIGURES 
CONTENTS 
INTRODUCTION. VARIETY OF TREATMENT—Continued. 
PRESENTATION OF THE CLINICAL Foreign protein—Continued. 
CASES. Nonsensitized vaccine. 
Period of observation. Intravenous. 
Source of material. Peptone. 
Type of epidemic. Intramuscular. 
Morbidity and mortality. Milk, 
Selection of material. Intramuscular. 
Clinical grouping of cases. Colloidal preparation. 
VARIETY OF TREATMENT. Colloidal gold (colibiase). 
Foreign protein. Intravenous. 
Sensitized vaccine. DISCUSSION. 
Intravenous. Specificity of the treatment. 
Controls. Nonspecificity of the treatment. 
Intramuscular. SUMMARY AND CONCLUSIONS. 
INTRODUCTION 
Life is short and art long; opportunity is fleeting; experiment is 
dangerous and decision is difficult.—First Aphorism of Hippocrates. 
The question of the therapy of typhoid fever has been given 
considerable attention by scientists for the last three years. It 
now forms a new field of scientific research, among both clin- 
icians and laboratory workers. Medical literature teems with 
reports of the favorable results obtained by different observers 
of the merits of the various methods employed; namely, the use 
of (a) foreign proteins and (b) colloidal preparations. These 
methods of treatment may be said to be still in the experimental 
stage. After three years of careful trial and observation, the 
views expressed by leading investigators with particular refer- 
‘Thesis submitted in partial fulfillment of the requirements for the 
degree of Doctor of Tropical Medicine, in the Graduate School of Tropical 
Medicine and Public Health, University of the Philippines, February 21, 
1918. 
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