XIV, 1 Lantin: Treatment of Typhoid Fever 27 
If th day. } 12 th day. 13 th day. 14th day 15 th doy. 16th day. 
AMT eM |AM.| OP OM. AM: P.M. AMP M.|AM| PM, AM.[P M. 
iS 26 Wi26 1026 026 Wi2)\24+6 8 1212 46 810l2\2 6 12 6 0\2 6 10i'2 6/126 WiI26 
» 
Fe 
Sit = S 
= hi S 
Sane 31] 8 
= S 
ese |i] |B 
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#1 re St 
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se secs 
Bis o 
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N. o O 
Noo 
Fic. 4. Temperature chart of N. C. Benefited type of typhoid fever treated with sensitized 
typhoid vaccine intravenously. 
reach a normal or a subnormal level about twelve hours after 
injection. The rigor is followed by thirst, cold perspiration, and 
relaxation, but accompanied by a feeling of marked alleviation 
of subjective symptoms. In the majority of instances the pa- 
tient, previously sleepless, is able to sleep soundly the following 
night. | 
The temperature may remain permanently at the normal 
level, and in this event no further injection is necessary; but, if 
the temperature should rise again for a period of three or four 
days, another injection is needed with increasing dose. My ex- 
perience is that two or three doses are sufficient to produce 
the desired result; if without result, further injections seem to 
be of no value. 
According to Gay and Chickering,(11) and MeWilliams, (34) 
there is a leucopenia during the rise of temperature, and hyper- 
leucocytosis during the apyretic period. They were able to ob- 
serve these phenomena by frequently examining the blood of 
the patients. I was unable to make frequent examinations of 
the blood of the patients injected, but examination of the blood 
twenty-four hours after injection revealed a slight increase in 
the leucocyte count. 
I have observed that a moderate reaction is very necessary 
to produce beneficial results. Similar observations have been 
confirmed by Gay(9) and claimed by Leake. (24) To avoid 
errors in interpretation of results, it is highly advisable to base 
one’s judgment on the effects of treatment; that is to say, not 
from the subjective symptoms, but rather from the objective 
phenomena, such as shortening of the duration of the fever or, 
