XIV, 1 Lantin: Treatment of Typhoid Fever 387 
Symptomatology.—The symptoms observed were similar to 
those that had been met with in the patients treated with sen- 
sitized vaccine. 
Dosage.—Dithorn and Schultz used 70 to 300 million bacteria 
as their dosage, Miller and Lusk(29) used 200 millions, and 
McWilliams(34) used 250 to 500 millions. The doses used in 
this investigation range from 200 to 250 millions. Gay and 
Chickering(11) state that, if ,an overdose is administered, 
alarming or dangerous symptoms may supervene. 
Complications.—There were three cases that had lobar pneu- 
monia as a complication before treatment was begun, and one 
developed intestinal hemorrhage three days after injection. 
Table XIV shows the number of cases and the kind of com- 
plication that developed. 
TABLE XIV.—Complications before and during treatment. 
Before | During 
treat- treat- 
ment. ment, 
Lobar pneumonia..._.-....---------- -------- ---- ---- -----2-- 22-2 enn nnn nnn 3 0 
Intestinal heemorrhage--.--.--------------------------------------------------- 0 al 
"Totand ns Sa ee en a sp a es wo tee cone an - ote 1 
a Appeared three days after injection and recovered. 
It will be seen in Table XIV that there was but one case in 
which the treatment might be suspected as having been the 
cause of intestinal hemorrhage, but there was not sufficient 
clinical evidence to support the suspicion. In this case the 
hsemorrhage did not appear until three days after the injection, 
while McWilliams(34) recorded in her paper five cases reported 
by Boral, by Csernel and Marton, by Léwy, by Luksch and 
Wilhelm, and by Paulicek, in which it was evident that intes- 
tinal hemorrhage, terminating fatally, followed the injection. 
One of Eggerth’s patients developed a hemorrhage from the 
lungs and died: three hours after the injection. 
Mortality.—The mortality in nine cases is one, giving a mor- 
tality rate of 11.1 per cent. This case was deemed hopeless on 
admission, and autopsy findings indicate that the patient died 
of the so-called “typhoid accidents.” 
Autopsy findings (nonsensitized intravenous treatment). 
File No. 2302: P. N. He ae 
Anatomic diagnosis: Ulcerative enterocolitis, typhoid; acute splenitis; 
acute lymphadenitis; typhoid; marked focal necrosis, liver; miliary 
tuberculosis, pleura; acute parenchymatous nephritis; parenchy- 
matous degeneration of the heart. 
