day. Sth day. 9th Jay. /0th day. Mth day. 42 th day. 3 th day. 
AT ACMA 7 a 5 a 1A.MIE MIA MIP MIA.MSNP M.. 
26 10|\2 6 10\2 6 10\2 6 IW2 6 10\2,6 10 
> 
= 
Do) 
= 
h 
= 
NP 
siX 
Ny 
ak 
sik 
NS 
of? 
sik 
Nin 
n 
siz 
Mp 
n 
six 
Nh 
n 
sk 
Shy 
% 
MaRS 
8, Centigrade 
Widal = 
PSec.intravenous —|\% 
NS a 
hd N SN 
37 Do. 
*#Ic. 10. Temperature chart of I. R. Showing benefited type of typhoid fever, treated with 
colloidal gold intravenously. 
Symptomatology.—Letulle described the symptoms that ap- 
peared after the intravenous injection as consisting of a tem- 
porary rise in temperature preceded by chills, occurring from 
fifteen to forty minutes after injection, and followed by fall 
in temperature, sweats, general weakness, and alleviation of 
subjective symptoms. With my limited opportunities for ob- 
servation, so far, I can only say that none of my cases developed 
chills. There is the possible exception of one patient who felt 
a slight sensation of chilliness, although his temperature showed 
a slight rise. Whether this difference of observation is due to 
racial insusceptibility of Filipino patients to the after effects of 
the treatment or whether the preparation on hand was defective 
are matters for future investigation. . 
Other symptoms observed were slight leucocytosis, temper- 
ature fall by lysis, remitting or intermitting temperature, and, 
rarely, fall by crisis. On the following day amelioration of 
the subjective symptoms may be marked. 
Contraindications.—Letulle does not believe that delirium and 
high fever, tachycardia, small pulse, or albuminuria are contra- 
indications for the intravenous injection. According to him the 
kidney continues to function well, for polyuria appears after 
injection. He observed neither intestinal hemorrhage nor per- 
foration. 
It is not improbable that nephritis may be produced after a 
long-continued use of this preparation, because metals generally 
have an irritating effect upon the renal epithelium. This con- 
ception is supported by the experiment undertaken by Schébl 
in which he found marked nephritis in the kidneys of animals 
experimented upon with intravenous injection of colloidal silver 
preparation. 
* Chief of the serum section of the Philippine Bureau of Science. 
