312 National Vaccine EsiaU'ishment . 



Constitutional Symptoms, 



Constitutional symptoms sometimes occur at a very early 

 period, but more commonly from the seventh to the ele- 

 venth day. These are drowsiness, restlessness, a chilliness 

 succeeded by heat, thirst, head-ach, and other marks of 

 febrile affection. Now and then sickness or vomiting takes 

 place, especially in infants. 



The constitutional symptoms are in general slight and 

 transient. 



in a great proportion of cases there is no perceptible in- 

 disposition ; nevertheless, the person vaccinated is not the 

 less secure from the future infection of the small-pox, pro- 

 vided the progress of the vesicle has been regular and com- 

 plete. 



Care should be taken not to confound the symptoms of 

 other diseases with those produced by vaccine inoculation. 



Medical Treatment, 

 In general no medicine is required in this mild affection ; 

 but if the symptoms happen to run a little higher than 

 nsual, the same remedies are to be applied as if they pro- 

 ceeded from any other cause. 



No preparatory medicines are necessary before vaccinating, 

 and commonlv no cathartics need be given afterwards. 



Should the local inflammation exceed the usual bounds, 

 which rarely happens, unless from tight sleeves, pressure, 

 or friction, it may soon be checked by the frequent appli- 

 cation of compresses of linen dipped in water, in liquor 

 Plumbi Acetatis dilutus, or in a solution of one drachm of 

 Plumbi Superacetas in a pint of water. These are to be 

 applied cold. 



If the scab be rubbed off prematurely, and ulceration take 

 place, cooling and astringent applications may be used ; such 

 as a drop of liquor Plumbi Acetatis, which should be allowed 

 to dry on the part, and then be covered with compresses 

 dipped in water, or in either of the preparations of lead 

 above-mentioned, and frequently renewed. 



When ulceration is deep or extensive, a poultice either of 

 bread and milk, or of bread with any of the preparations of 

 lead may be applied, as the case seems to require. They 

 must never be applied till they are nearly or quite cold. 



In Such foul and obstinate sores as resist the foregoing 

 applications, the Unguentum Hydrargyri Nitratis, mixed 

 with an equal quantity o\^ Unguentum Cetacei or other si- 

 milar applicat : * - nipy sometimes be resorted to with advan- 

 tage. And at other times these sores may be healed by the 

 Ceratum Plumbi Superacetatis, or the mildest applications. 



The 



