294 THE V1TAMINES 



according to our procedure, while in wet beriberi it was ineffective. 

 From this, it was concluded that for the therapy of various types of 

 beriberi, vitamines of various sources were necessary. This observa- 

 tion may be explained by the severity of the symptoms, without 

 having recourse to such a hypothesis. Good results with vitamine 

 preparations were obtained by Williams and Saleeby (I.e. 472). 

 Later on, Saleeby (898) used autolyzed yeast in adults and children. 

 The dose used was 15 to 40 cc. three times daily for adults, and 2 to 4 

 cc. every 3 hours for children, greater doses being of no advantage. 

 Marked results were noted after 3 days, but the treatment was con- 

 tinued for 14 days more. In infants, the results were noticeable even 

 sooner. A standardization of the extract of rice polishings was 

 recommended by tel Rosario and Maranon (899). In the late war, a 

 yeast preparation (marmite) was used in the English army with 

 splendid results (Willcox, I.e. 864). Hepburn (I.e. 845) too reported 

 results with the vitamine therapy in Siam. 



Therapy in infantile beriberi 



This consists either of a change of milk, or of the administration of 

 vitamine. Particularly good results were obtained with an extract 

 of rice polishings (tiki-tiki). According to Albert (900), the symp- 

 toms disappear in a few days, sometimes after a few hours. Cox 

 (901) remarked particularly on the decrease in the number of cases 

 of infantile beriberi in the Philippines since the introduction of 

 vitamine therapy. 



It need hardly be said that poor results have also been obtained 

 by the use of vitamine therapy. What we said about avian beriberi 

 applies here also, namely, that for a successful vitamine therapy it 

 is necessary throughout that the anatomical changes should not have 

 progressed too far. 



SHIP-BERIBERI 



It is theoretically quite possible that vitamines B and C should 

 both be lacking in the diet, and in this way give rise to a mixed form 

 of scurvy and beriberi. Such mixed forms have not been described 

 with great certainty, but it would be possible to regard ship-beriberi 

 as such. The various investigators are not agreed as to the nature 

 of this type of beriberi. It occurs on sailing vessels, when the supply 



