LIBRARY 



CHAPTER X 



INFLUENCE OF NUTRITION (VITAMINES) ON THE ACTION OF SOME 



POISONS AND UPON PATHOLOGICAL CONDITIONS OF 



NON-INFECTIOUS ORIGIN 



The older papers of Reid Hunt have already shown that changes 

 in the diet are not without effect on the toxicity of different drugs. 

 Similarly Reach (1535) has shown that the resistance towards the 

 cramps-producing poison, picrotoxin, is greater in mice on a meat 

 diet than on a bread diet and he assumed that he probably had to 

 deal with the action of some unknown substances. Salant (1536) 

 and Salant and Swanson (1537) observed that young carrots had a 

 far greater protective action against the poisonous effect of sodium 

 tartrate in rabbits, than did old carrots. The same results were 

 obtained with sweet potatoes and carrot leaves. On oats and sugar, 

 the toxicity was markedly increased, and the differences found were 

 not due to increased diuresis. Cats behave otherwise, no difference 

 being apparent; here too, however, the effect of the poison was 

 increased about 40 per cent in starvation. 



ANEMIA, ETC. 



Here we have the work of Pearce, Austin and Pepper (1538), who 

 studied the influence of the diet in anemia, after splenectomy. They 

 observed in dogs that raw meat acts much better than cooked, and 

 they thought this difference was due to the vitamine content. Mad- 

 sen (1539) is of the opinion that the vitamines play a part in chlorosis 

 and anemia. Geiling and Green (1539a) subjected this question 

 to experimental test. If rats were given a diet poor in protein vita- 

 mines or salts, then the blood regeneration after a hemorrhage was 

 markedly retarded. Davis, Hall and Whipple (1540) produced 

 necrosis of the liver by chloroform and studied the effect of different 

 diets on the regeneration of liver cells. Muscle tissue and fats of 

 various sources were without effect but feeding of liver, kidney and 

 brain resulted favorably. 



Campbell (1541) and van der Bogert (1541a) thought that the 

 occurrence of adenoids in children is of dietetic origin, but we do not 



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