390 THE VITAMINES 



Benedict (1572). Van Alstyne and Beebe (1573) believed that they 

 had stimulated tumor growth by the addition of lactose to an artificial 

 diet, but this was evidently due to a contamination of the lactose 

 with vitamine B. In a similar manner, the author (I.e. 244, 245, and 

 246) showed in 1913 on chickens, that the chicken sarcoma of Rous 

 grows much slower on a vitamine-poor diet than on one rich in vita- 

 mines, and these results were confirmed by Drummond (I.e. 247). 

 Levin (1574), however, could not corroborate these findings and 

 Frankel and Fiirer (1575) expressed themselves against this phase of 

 cancer research. The few negative results, naturally, cannot have 

 any effect on our conclusions in comparison with the conformity of 

 the conclusions of a great number of investigators in this field. 

 Undoubtedly, the restriction of the vitamines in the diet markedly 

 inhibits the growth of neoplasms. This measure would have been 

 of practical value, if it had not been evident that the tumor tissue 

 shows a greater affinity for the vitamines than does the somatic 

 tissue. This indicates that in order to obtain a complete success, 

 the vitamines would have to be so far curtailed that the organism 

 itself would die. That certain substances govern tumor growth, is 

 evident from the paper by Rondoni (1576), who showed that the 

 sarcoma tissue could favorably influence the growth of experimental 

 tumors. The same conclusions were obvious from the work of 

 Murphy (1577), who allowed rat tumors to grow in chicken embryo, 

 it being impossible to do so in grown chickens. From this, it is 

 evident that in rapidly growing embryonic tissue, a substance is 

 present which stimulates the growth of neoplasms. That this view 

 is justified, is clear from the work of Funk (1578), who showed that 

 when the mouse chondroma of Ehrlich is implanted in the rat, the 

 tumor tissue is resorbed in a few days. However, if the mouse tumor 

 is fed to the rat in large quantities, then not only does the tumor 

 develop but it may be transplanted in three generations of rats so 

 treated. Here, in our opinion, it cannot be denied that the mouse 

 chondroma contains a substance which acts specifically on the 

 growth of a similar tumor. At the same time, the influence of the 

 diet is shown very well. The induced tumor possessed, as the 

 illustration shows, for the most part, the same histological structure. 

 The dietetic restriction for the purpose of treating cancer has also 

 been used in practice. Bulkley (1579) used, for this purpose, a diet 

 so chosen that it contained almost no animal protein. Since this 



