308 THE VITAMINES 



Hematology 



A number of investigators have recorded their findings as to the 

 blood picture, but it does not appear that specific indications were 

 discovered. On this subject, there is the work of Labor (1005), 

 Leitner (1006), Brandt (1007), Wassermann (1008) and Benoit 

 (1009); the last investigator reported findings in 63 adults. Hess 

 and Fish (I.e. 975) made hematological studies in Barlow's disease, 

 including the clotting-time of the blood, which was found normal. 



As regards the chemistry of the blood, the sugar content was 

 determined in some cases by Roily and Oppermann (1010) as well 

 as Schumm (1011), and found normal. Hess and Killian (1012) 

 determined the calcium, sugar and urea content, as well as the dia- 

 static and the carbon dioxide combining power of scorbutic blood. 

 They found a moderate acidosis, and a smaller calcium content 

 (different from rickets) ; as for the rest, the values were normal. 



Metabolism experiments 



Bauman and Howard (1013) investigated the inorganic metab- 

 olism in one case of adult scurvy. The chlorine and sodium balances 

 were negative and were not much more favorably affected by the 

 administration of antiscorbutics. The sulphur metabolism in adults 

 was found abnormal by Labbe, Haguinea and Nepreux (1014). 

 The case investigated was, perhaps, in the convalescent stage and 

 was marked by a large urea output, indicative, possibly, of the 

 disappearance of edema. Experiments in an older child were carried 

 out by Lust (1015), and especially by Lust and Klocman (1016). 

 The child showed a retention of all inorganic constituents, which 

 were subsequently eliminated after a cure; this applies, in particular, 

 to calcium. These data, which seemed to be somewhat uncertain 

 at first, appear now to be corroborated. As for the calcium metab- 

 olism, the above results were confirmed by JVLoll (1017). Frank 

 (1018), experimenting with two cases, found a calcium retention in 

 the acute stage; during convalescence, this calcium was again 

 eliminated. 



Pathology of scurvy 



A splendid monograph on this subject is that of Aschoff and Koch 

 (Lc. 981) as well as of v. Samson-Himmelstiern (cited by Aschoff 

 and Koch, I.e. 981); with the exception of severe cases, only well 



