69 



The hypophysial components 



The endocrine disturbance leading to the abnormal condition 

 of the epithelial bodies, the thyroid and adrenal glands, sub- 

 sequently to be described, has of necessity been mediated to 

 these distant organs by the blood stream. The neural hy- 

 pophysis, while subjected as are these other glands to this general 

 endocrine disturbance, has, in addition, been subjected to the 

 loss of its intimate anatomical associate, the epithelial hypophy- 

 sis, a loss which in itself might conceivably greatly modify the 

 neural lobe entirely apart from the general disturbance intro- 

 duced into this correlative system of organs by buccal hypo- 

 physectomy. That the intimate anatomical association exist- 

 ing between the neural and epithelial components, to which 

 attention has been called by many observers, 32 is fundamental 

 for the elaboration of the secretion of at least the posterior lobe, 

 finds support not only in the anatomical evidence afforded by 

 this relationship, but also in the recent work of Schmidt and 

 May from the chemical side. 33 As will be pointed out, cor- 

 roborative evidence bearing upon the significance of this coales- 

 cence will accrue from this study. It must be kept in mind 

 that in this experimental work the buccal constituent of this 

 gland has been removed prior to the union with its neural asso- 

 ciate, which consequently remains undisturbed, and that the 

 infundibular process at this time gives no indication- of the 

 structural differentiation which it is to later undergo, so that 

 any modifications exhibited by the neural lobe (or the infundibu- 

 lar process) are not referable to any direct operative injury 

 inflicted upon this member. As will be subsequently pointed 

 out more in detail, sections and models of these albinos reveal 

 a profound reduction in size, as well as an atypical shape and 



"Herring, Trautmann, Stumpf, Kohn, Erdheim and Stumme, Vogel, Stendel, 

 and others. 



33 Schmidt and May, by appropriate chemical treatment of the alcoholic hy- 

 pophysial extract, Tethelin, have secured a substance whose action simulates the 

 active principle of the posterior lobe, i.e., causes a contraction of the isolated uterus 

 and produces a vasoconstriction. 



