THE PARS BUCCALIS OF THE HYPOPHYSIS 97 



and their characteristics described. Especial interest is associ- 

 ated with these specimens in the study of the adrenal, since the 

 pigmentation in Addison's disease is usually referred to a de- 

 rangement of the adrenal. Both whole mounts and sections, 

 however, reveal the fact that neither the adrenal cortex nor 

 medulla suffers a serious disturbance in the 'partial' albino as 

 compared with the normal animal. To test more exactly the 

 amount of cortex in one such specimen, it was reproduced in wax 

 (x300), as has been previously explained. These findings show 

 that the cortical tissue is present in relatively as great an amount 

 as in the normal tadpole (table 9). Apparently, then, as in the 

 case of the thyroid, a relatively small amount of hypophysial 

 tissue is sufficient to give rise to a normal adrenal. 



The epithelial bodies 



The epithelial bodies (Maurer) might be suspected of par- 

 ticipating in the general endocrine upset experienced by the 

 tadpole suffering from pituitary deficiency. Such, indeed, ap- 

 pears to be the case, although these bodies do not suffer as do 

 the thyroids, adrenal cortex, or neural hypophysis. Models of 

 these glands made from four normal and four albinous tadpoles 

 reveal in many cases a profound diminution in the albino, al- 

 though in other cases this decrease does not transcend the limits 

 of variation of the individual bodies in the normal. When we 

 take cognizance of the total amount of tissue, however, there 

 can be no question but that it is profoundly diminished in the 

 albino (table 11). There appears to be no serious structural 

 abnormalities in these bodies. Thus in their reaction to epi- 

 thelial hypophysectomy these bodies align themselves with all 

 the other endocrine organs thus far examined (thyroids, adrenal 

 cortex, neural hypophysis) save one, the adrenal medulla. An 

 opposite response one of increasing size is evoked in the 

 epithelial bodies (Allen) by thyroidectomy. In this opposed 

 response in thyroidectomy they thus align themselves with the 

 enlargement which the pituitary (Allen, Hoskins) and adrenal 

 cortex (Smith) enjoy. 



MEMOIR NO. 1 1. 



