428 CHARLES R. STOCKARD AND E. M. VICARI 



see beyond that there is also evidence of macroscopic arrests 

 in the morphology of the pituitary gland, with large, plump 

 suprarenals and frequent accompanying deficiencies in gon- 

 adal development, such as failure in descent of the testes, 

 and defective oestrus with sterility and abnormally small 

 litters in the female. 



The microscopic structure of the thyroid gland in the 

 French bulldog (fig. 2, pi. 81) is very much on the same 

 general pattern as that for the English bulldog. The follicles 

 in the French bulldog thyroid are extremely irregular in 

 outline, although somewhat larger than in the English breed. 

 Extrafollicular colloid is also found in this gland, and the 

 microscopic picture of hyperthyroidism is somewhat more 

 genuine, with high columnar epithelium and secretion drop- 

 lets shown in most follicles. This dog is very nervous and 

 hyperactive, with varying degrees of exophthalmos, all com- 

 mon symptoms of thyroid oversecretion. The thyroid, as in 

 all the bulldogs, has an excessive amount of extrafollicular 

 tissue, and lying within this are rather small groups of para- 

 follicular cells. Although we have examined thyroids from 

 only a few French bulldogs, their histology has been quite 

 consistently of the same general pattern as shown in this 

 photomicrograph. 



Together with the bulldog sections in plate 81 are photo- 

 micrographs of the thyroids from the bassethound and the 

 foxhound. The contrast in histologic patterns between the 

 bulldog thyroids and those of the hounds is strongly marked. 

 The bassethound, although having extreme chondrodystrophy 

 of the legs, has a thyroid gland (fig. 3) almost indistinguish- 

 able in its normal histology from that of the long legged 

 foxhound (fig. 4). If chondrodystrophy of the basicranium 

 in the bulldog were related, either directly or indirectly, to 

 the histopathology of its thyroid gland, certainly then the 

 chondrodystrophy in the bassethound legs might be expected 

 to accompany a somewhat similar thyroid condition. Since, 

 however, this is not the case, the thyroid gland can scarcely 



