GENETIC TYPE AND THE ENDOCRINES 457 



pituitary is shown in the photomicrograph from 436 2 in 

 figure 1 of plate 88. An enormous cyst filled with mucoid 

 substance is seen extending entirely across the anterior region 

 of the pars distalis ; two others lie at the periphery, only one 

 of which shows in this section, and a smaller one lies in the 

 margin of the tuberalis. These cysts are lined by columnar 

 epithelium which is distinctly ciliated in places. The cord-like 

 arrangement of the glandular cells is show r n throughout the 

 extent of the anterior pituitary. The pars intermedia contains 

 numerous small colloidal follicles. The basophiles in this 

 gland are in unusually low proportion to the acidophiles. and 

 the entire gland gives the impression of being stained a 

 bright red. 



In spite of the extremely pathologic nature of this pituitary 

 as compared with the normal dachshund gland (fig. 2), the 

 Boston terrier bitch possessing it had produced two litters 

 of three and four puppies, and successfully reared several 

 of them. The size of these litters is comparatively small 

 for dogs, and the bitch was somewhat abnormal in maternal 

 reactions. Although appreciating these defects, it still 

 seems surprising that an animal possessing so distorted 

 a pituitary gland, with the associated modifications of 

 the thyroid which have already been cited for the breed, 

 could produce full term viable offspring and react to them 

 in an even partially successful manner. This case at least 

 suggests that some of the responsibility which has been at- 

 tributed to the histopathology of human pituitaries in cases 

 with diseases of growth and malfunction may not always be 

 accurately placed. 



It must be repeated that not every individual of the Boston 

 terrier breed presents such gross distortions of the pituitary 

 as those just described. This photomicrograph was selected 

 to emphasize how very different the modifications in the 

 Boston terrier gland are from those tendencies we have 

 examined in the dachshund. Thus arises the point of interest 

 as to whether the developmental arrests and defects of the 



