512 CHARLES B. STOCKARD AND E. M. VICARI 



chromophobes present. The acidophiles are somewhat smaller 

 than is usual and stain a dull deep red, and the dark nuclei 

 are filled with coarse chromatin granules. Basophiles are 

 difficult to find and there is only one to about 600 acidophilic 

 cells. The few basophiles are evenly filled with fine cytoplasmic 

 granules. 



The pars distalis presents an almost perfect histologic 

 picture of the acidophilic adenomata or true hyperplasia of 

 acidophiles associated with human acromegalic gigantism. 

 As Gushing ( '12) and Gushing and Davidoff ( '27) have stated, 

 no one today can have any reasonable doubt that the hormones 

 or the substance provoking overgrowth are a product of 

 these acidophilic cells. In the present case we have the first 

 clear demonstration that acromegalic constitution may be 

 brought about through strange combinations of qualities 

 within the hybrid progeny derived from two non-acromegalic 

 stocks. 



Figure 2 in plate 96 illustrates a longitudinal section of 

 the pituitary gland from another acromegalic-like F 2 hybrid. 

 This dog, 977 $ , is shown from life in plate 58 (fig. 5) where 

 his short legs hide to some extent the strongly expressed 

 short haired St. Bernard type. The skull of this animal is 

 shown as figure 16 in plate 57. The head and body type, as 

 well as the skull with its normal dental occlusion, all closely 

 follow the St. Bernard in form and quality; the only dis- 

 senting feature is the short achondroplasic legs. The 

 general morphology of the pituitary from this animal re- 

 sembles more closely that of the St. Bernard than it does 

 either the bassethound or bulldog. It is long, flat and oval 

 in outline and in general shape resembles pituitaries from 

 the hound-like group. The dorsal surface of the pars nervosa 

 is not, however, covered by the distalis, and the pars inter- 

 media folds and penetrates deeply into the body of the 

 nervosa from its distal end; the latter feature is never seen 

 in either the bassethound or the bulldog glands. The pars 



