GENETIC TYPE AND THE ENDOCBINES 717 



the C-R might be accounted for in part by the resulting low 

 thyroid condition. To test this hypothesis, the dog was given 

 thyroid extract, 2 gms. daily, subcutaneously, for 24 days. 

 The result of this procedure was instructive. The response 

 reappeared and gained considerably in magnitude, although 

 it never attained the normal level, and continued fairly brisk 

 for some time after the substance was withdrawn, when 

 it completely disappeared. This stage was approximately 5 

 months after the operation. 



The dog's behavior outside the laboratory was at first only 

 slightly affected. The most noticeable sign was a certain 

 slowness in general body movement. The gait in walking 

 was normal. Appetite was unaffected. As time went on, the 

 effects became more pronounced. At the end of the fifth 

 month the dog had become extremely fat; the body had a 

 decidedly barrel-shaped appearance, and the head seemed 

 much too small in proportion. The fat hung in folds about 

 the neck and trunk. The muscles were flabby. The skin was 

 in fair condition but was noticeably dry and scaly. All skeletal 

 movements were exceedingly slow. The gait in walking was 

 now very much affected. It was a definitely staggering, stiff- 

 legged walk in which the head bobbed about in an uncertain, 

 tremulous and uncoordinated manner. When attempt was 

 made to have her run, the gait was a series of curious bowing 

 movements which carried her from one side of the long run 

 to the other. She occasionally ran against the fence as 

 though unable to see it. When at the water pail for a drink, 

 she did not seem able to locate the surface of the water 

 accurately. She would stand over the pail, head bobbing 

 aimlessly about, and her nose frequently went under the 

 surface almost to the bottom of the full bucket. Muscular 

 action was weak, as illustrated by the fact that she could be 

 easily pushed over. 



At this stage pituitary transplants were tried. The fresh, 

 whole pituitary taken from a dog at autopsy was directly 

 transferred under aseptic conditions to a "pocket" in the 

 pectoralis major muscle. Such a transplant was made three 



