504 CHARLES R. STOCKARD AND E. M. VICARI 



cystic formations occur at this point of fusion, and smaller 

 cysts are present near the periphery in other parts of the 

 distalis. The epithelial cells of the distalis show cord-like 

 arrangements with excessive amounts of connective tissue 

 separating them. All in all there is an abnormally small 

 amount of secretory epithelium in the pars tuberalis and 

 distalis. The alpha or acidophilic cells are bright staining 

 and in high proportion, there being more than thirty acido- 

 philic cells to one basophilic. The basophiles are frequently 

 vacuolated, and signet typed castrate cells are seen. The 

 relative proportion of acidophilic to basophilic cells is almost 

 the reverse to that following operative castration and meno- 

 pause, and yet the cytological quality of the basophiles is 

 suggestive of the so-called castrate cells. As we have seen, 

 the pituitary of the Boston terrier is in many ways not unlike 

 that of the bulldog. 



The pituitary glands from eight male and six female bull- 

 dogs have been studied microscopically, and while they are 

 not uniformly alike in detail their general qualities are closely 

 similar. The pars nervosa, intimately coated by the inter- 

 media, is easily detached from the anterior lobe, and re- 

 moval of the gland from the sella turcica must be performed 

 with great care in order to preserve it intact. The pars 

 tuberalis does not completely surround the short infundibular 

 stalk, and the upper border of the cup-shaped pars distalis 

 extends slightly above the equator of the nervosa. A common 

 feature of the bulldog pituitary is the persistence of a mem- 

 branous connection between the anterior lobe and a depression 

 in the basisphenoid ; in rarer cases, a complete foramen is 

 present permitting the direct continuation between the glandu- 

 lar pituitary, Rathke's pouch, and the oral epithelium. All 

 the above features vary among the fourteen glands in our 

 series, yet they are constant enough to enable one to dis- 

 tinguish the bulldog pituitary from that of the long muzzled 

 breeds. On the basis of this experience, one would not expect 

 a flattened elongate pituitary with extensive pars distalis 

 in the bulldog, and should a pituitary of apparently this type 



