GENETIC TYPE AND THE ENDOCBINES 513 



distalis is compact, its cells are arranged close together with 

 only sparse intervening connective tissue, and the cord-like 

 arrangements are indistinct. Again the acidophilic cells are 

 the outstanding type, the chromophobes being less abundant 

 and the basophiles very rare. 



The three brothers and the St. Bernard-like F 2 male from 

 which the pituitaries in plate 96 were taken, differed from 

 one another in readily recognizable ways, and the histologic 

 patterns of their pituitaries seem to show differences in 

 close association with the differences in morphologic type. 

 In other words, the pituitary of the strongly pronounced 

 bulldog breed is rather characteristic in morphologic struc- 

 ture, and the same is true to a greater or lesser degree for 

 the bassethound. In physical form, some individuals among 

 the second generation hybrids between two such breeds tend 

 to resemble one parent stock and some the other, and these 

 resemblances are associated with the microscopic pattern of 

 pituitary which is characteristic for the breed approached. 

 Eccentric individuals also appear among the second gen- 

 eration hybrids. These may differ widely from the two parent- 

 al stocks and present conditions foreign to both breeds. These 

 strange growth reactions arising from new combinations of 

 qualities may resemble distortions commonly known in other 

 breeds or even again a well recognized pathologic state. 

 In such cases the pituitary glands of these erratic individuals 

 present histologic modifications well known to be closely as- 

 sociated with the specific physical deviations concerned. Many 

 of these erratic combinations emphasize the dangers and dis- 

 advantages of breed hybridization from the standpoint of 

 disbalance in endocrinic constitution. 



Before making further comparisons between the endocrinic 

 qualities found in the present cross with those of the Boston 

 terrier-dachshund hybrids previously discussed, the para- 

 thyroid glands from the bassethound-bulldog generations will 

 be examined. 



